Assessing the sensitivity of placental growth factor and soluble fms-like tyrosine kinase 1 at 36 weeks' gestation to predict small-for-gestational-age infants or late-onset preeclampsia: a prospective nested case-control study

BMC Pregnancy and Childbirth
Teresa M MacDonaldStephen Tong

Abstract

Fetal growth restriction is a disorder of placental dysfunction with three to four-fold increased risk of stillbirth. Fetal growth restriction has pathophysiological features in common with preeclampsia. We hypothesised that angiogenesis-related factors in maternal plasma, known to predict preeclampsia, may also detect fetal growth restriction at 36 weeks' gestation. We therefore set out to determine the diagnostic performance of soluble fms-like tyrosine kinase 1 (sFlt-1), placental growth factor (PlGF), and the sFlt-1:PlGF ratio, measured at 36 weeks' gestation, in identifying women who subsequently give birth to small-for-gestational-age (SGA; birthweight <10th centile) infants. We also aimed to validate the predictive performance of the analytes for late-onset preeclampsia in a large independent, prospective cohort. A nested 1:2 case-control study was performed including 102 cases of SGA infants and a matched group of 207 controls; and 39 cases of preeclampsia. We determined the diagnostic performance of each angiogenesis-related factor, and of their ratio, to detect SGA infants or preeclampsia, for a predetermined 10% false positive rate. Median plasma levels of PlGF at 36 weeks' gestation were significantly lower in women...Continue Reading

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Citations

Jul 13, 2019·Prenatal Diagnosis·Stephen TongTeresa Mary MacDonald
Sep 29, 2019·Hypertension in Pregnancy : Official Journal of the International Society for the Study of Hypertension in Pregnancy·Manouk L E HendrixSalwan Al-Nasiry
Sep 19, 2019·TheScientificWorldJournal·Debora F B Leite, Jose G Cecatti
Jan 1, 2020·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Katharine M IrvineSailesh Kumar
Oct 24, 2020·Scientific Reports·Carole-Anne WhighamTu'uhevaha J Kaitu'u-Lino
Aug 8, 2021·Journal of Clinical Medicine·Natalie K BinderNatalie J Hannan

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Methods Mentioned

BETA
SGA

Software Mentioned

GROW
Stata
GraphPad
GraphPad Prism
LOWESS

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