Assessing the strength of cardiac and sympathetic baroreflex controls via transfer entropy during orthostatic challenge

Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences
Alberto PortaMathias Baumert

Abstract

The study assesses the strength of the causal relation along baroreflex (BR) in humans during an incremental postural challenge soliciting the BR. Both cardiac BR (cBR) and sympathetic BR (sBR) were characterized via BR sequence approaches from spontaneous fluctuations of heart period (HP), systolic arterial pressure (SAP), diastolic arterial pressure (DAP) and muscle sympathetic nerve activity (MSNA). A model-based transfer entropy method was applied to quantify the strength of the coupling from SAP to HP and from DAP to MSNA. The confounding influences of respiration were accounted for. Twelve young healthy subjects (20-36 years, nine females) were sequentially tilted at 0°, 20°, 30° and 40°. We found that (i) the strength of the causal relation along the cBR increases with tilt table inclination, while that along the sBR is unrelated to it; (ii) the strength of the causal coupling is unrelated to the gain of the relation; (iii) transfer entropy indexes are significantly and positively associated with simplified causality indexes derived from BR sequence analysis. The study proves that causality indexes are complementary to traditional characterization of the BR and suggests that simple markers derived from BR sequence analys...Continue Reading

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Citations

Nov 9, 2017·Frontiers in Physiology·Ajay K VermaKouhyar Tavakolian
Feb 15, 2018·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Michal JavorkaMathias Baumert
May 17, 2017·Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences·José M Amigó, Michael Small

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