Assessing the utility of Xpert(®) MTB/RIF as a screening tool for patients admitted to medical wards in South Africa

Scientific Reports
Christine L HeidebrechtDouglas Wilson

Abstract

Many hospital inpatients in South Africa have undiagnosed active and drug-resistant tuberculosis (TB). Early detection of TB is essential to inform immediate infection control actions to minimize transmission risk. We assessed the utility of Xpert(®) MTB/RIF (GeneXpert) as a screening tool for medical admissions at a large public hospital in South Africa. Consecutive adult patients admitted to medical wards between March-June 2013 were enrolled; sputum specimens were collected and tested by GeneXpert, smear microscopy, and culture. Chest X-rays (CXRs) were conducted as standard care for all patients admitted. We evaluated the proportion of patients identified with TB disease through each diagnostic method. Among enrolled patients whose medical charts were available for review post-discharge, 61 (27%) were diagnosed with TB; 34 (56% of diagnosed TB cases) were GeneXpert positive. When patients in whom TB was identified by other means were excluded, GeneXpert yielded only four additional TB cases. However, GeneXpert identified rifampicin-resistant TB in one patient, who was initially diagnosed based on CXR. The utility of GeneXpert for TB screening was limited in an institution where CXR is conducted routinely and which serves a ...Continue Reading

References

Aug 5, 1999·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·L V SacksC Constantinou
Nov 6, 2009·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·D SissolakS Mehtar
May 22, 2010·Lancet·Knut LönnrothMario C Raviglione
Aug 20, 2010·Journal of Clinical Microbiology·Padmapriya P BanadaDavid Alland
Sep 9, 2010·South African Medical Journal = Suid-Afrikaanse Tydskrif Vir Geneeskunde·Colleen M Bamford, Jantjie J Taljaard
Sep 10, 2010·The New England Journal of Medicine·Catharina C BoehmeMark D Perkins
Jan 13, 2012·The International Journal of Tuberculosis and Lung Disease : the Official Journal of the International Union Against Tuberculosis and Lung Disease·A Van RieR Warren
Jul 19, 2012·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Justin O'GradyAlimuddin Zumla
Nov 21, 2012·The Journal of Infectious Diseases·Neel R GandhiN Sarita Shah

❮ Previous
Next ❯

Citations

May 22, 2017·Journal of Microbiological Methods·Promod K MehtaDhruva Chaudhary
Jun 13, 2018·The American Journal of Tropical Medicine and Hygiene·Stephanie GatiJacqueline M Achkar
Jun 8, 2019·The Cochrane Database of Systematic Reviews·David J HorneKaren R Steingart
Mar 30, 2017·The Journal of International Medical Research·Tingyu TangQingdong Huang

❮ Previous
Next ❯

Methods Mentioned

BETA
nucleic acid amplification

Software Mentioned

Stata
GeneXpert

Related Concepts

Related Feeds

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Antimicrobial Resistance (ASM)

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.

Antimicrobial Resistance

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Related Papers

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
Brian J Baker, Paul D Holtom
The International Journal of Tuberculosis and Lung Disease : the Official Journal of the International Union Against Tuberculosis and Lung Disease
A Van RieI Sanne
The Cochrane Database of Systematic Reviews
Karen R SteingartNandini Dendukuri
The International Journal of Tuberculosis and Lung Disease : the Official Journal of the International Union Against Tuberculosis and Lung Disease
N SomashekarSwami Japananda
The Cochrane Database of Systematic Reviews
Karen R SteingartNandini Dendukuri
© 2022 Meta ULC. All rights reserved