Assessing the Validity of Friedewald's Formula and Anandraja's Formula For Serum LDL-Cholesterol Calculation

Journal of Clinical and Diagnostic Research : JCDR
P Krishnaveni, Vanitha Mn Gowda

Abstract

An important aspect of the assessment of cardiovascular risk for a dyslipidemic subject is the estimation of serum Low-Density Lipoprotein Cholesterol (LDL-C). There are many homogenous assays currently available for the estimation of serum LDL-C. Most clinical laboratories determine LDL-C (mg/dL) by Friedewald's formula (FF), LDL-C = (TC) - (HDL-C) - (TG/5). Recently Anandaraja and colleagues have derived a new formula for calculating LDL-C, AR-LDL-C = 0.9 TC- (0.9 TG/5)-28. The aim of the study was: a) to determine if, and to what extent, LDL-C level was underestimated/overestimated when it was calculated using the formulae compared with direct measurement of LDL-C, and b) to determine which of the calculated formulae show maximum correlation with direct LDL cholesterol method at different TG levels. A cross-sectional study. Record analysis was done from the 370 (TG <400mg/dl) lipid profile reports of patients above 18 years. LDL-C estimation was done by homogenous assay and also calculated using the Friedewald's Formula and Anandaraja's Formula. The mean LDL-C levels were 105.17± 43.4, 102.98 ±42.5, and 98.20 ±43.7 mg/dl for D-LDL-C, F-LDL-C and AR-LDL-C, respectively. A good correlation was found between the calculated LDL-...Continue Reading

Citations

Sep 7, 2016·Journal of Clinical Laboratory Analysis·Mehdi Rasouli, Hossein Mokhtari
Sep 24, 2020·Journal of Diabetes Research·Anna S Huerta-DelgadoLeticia Elizondo-Montemayor
Jul 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Doga KavazHuzaifa Umar

❮ Previous
Next ❯

Related Concepts

Related Feeds

ApoE, Lipids & Cholesterol

Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.