PMID: 8948340Oct 1, 1996Paper

Assessing the variability of outcome for patients treated with localized prostate irradiation using different definitions of biochemical control

International Journal of Radiation Oncology, Biology, Physics
Eric M HorwitzAlvaro Martinez

Abstract

Biochemical control using serial posttreatment serum prostate specific antigen (PSA) levels is being increasingly used to assess treatment efficacy for localized prostate cancer. However, no standardized definition of biochemical control has been established. We reviewed our experience treating patients with localized prostate cancer and applied three different commonly used definitions of biochemical control to determine if differences in therapeutic outcome would be observed. Between January 1987 and December 1991, 480 patients with clinically localized prostate cancer received external beam irradiation (RT) using localized prostate fields at William Beaumont Hospital. The median dose to the prostate was 66.6 Gy (range 58-70.4) using a four-field or arc technique. Pretreatment and posttreatment serum PSA levels were recorded. Over 86% (414 of 480) of patients had a pretreatment PSA level available. Three different definitions of biochemical control were used: (a) PSA nadir < 1 ng/ml within 1 year of treatment completion. After achieving nadir, if two consecutive increases of PSA were noted, the patient was scored a failure at the time of the first increase; (b) PSA nadir < 1.5 ng/ml within 1 year of treatment completion. Afte...Continue Reading

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Citations

Oct 23, 1997·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·E M HorwitzA A Martinez
Aug 3, 2001·International Journal of Radiation Oncology, Biology, Physics·J M TaylorH M Sandler
May 23, 2002·International Journal of Radiation Oncology, Biology, Physics·Larry L KestinAlvaro A Martinez
Feb 28, 2003·International Journal of Radiation Oncology, Biology, Physics·Eric E K YeohMartin F Borg
Oct 1, 1996·International Journal of Radiation Oncology, Biology, Physics·R E Peschel
Jul 4, 1998·International Journal of Radiation Oncology, Biology, Physics·E M HorwitzG E Hanks
Mar 31, 1999·International Journal of Radiation Oncology, Biology, Physics·F A ViciniA A Martinez
Oct 19, 1999·International Journal of Radiation Oncology, Biology, Physics·F A ViciniA A Martinez
Dec 31, 2002·Urologic Oncology·Tony Y EngTerrence S Herman
Dec 31, 1997·The New England Journal of Medicine·S S Schoen
May 10, 2005·The Journal of Urology·Deborah A KubanWilliam U Shipley
May 29, 1999·International Journal of Radiation Oncology, Biology, Physics·F A ViciniA Martinez
Oct 19, 2010·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Jiayi HuangFrank A Vicini
Jul 21, 2009·International Journal of Radiation Oncology, Biology, Physics·Gustavo Arruda VianiSergio Luis Afonso
Oct 9, 2007·International Journal of Radiation Oncology, Biology, Physics·Mark K BuyyounouskiAlan Pollack
Apr 9, 2005·International Journal of Radiation Oncology, Biology, Physics·Mark K BuyyounouskiAlan Pollack
Nov 22, 2011·International Journal of Radiation Oncology, Biology, Physics·Jiayi HuangLarry L Kestin
Sep 20, 2005·International Journal of Radiation Oncology, Biology, Physics·Mark K BuyyounouskiAlan Pollack
Feb 1, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jeremy M G TaylorHoward M Sandler
Sep 24, 1999·Radiation Oncology Investigations·E M HorwitzG E Hanks

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