Assessing total retinal blood flow in diabetic retinopathy using multiplane en face Doppler optical coherence tomography

The British Journal of Ophthalmology
Alex D PechauerYali Jia

Abstract

To assess total retinal blood flow (TRBF) in diabetic retinopathy (DR) using multiplane en face Doppler optical coherence tomography (OCT). A 70 kHz spectral-domain OCT system scanned a 2×2 mm area centred at the optic disc of the eyes with DR and healthy participants. The multiplane en face Doppler OCT algorithm generated a three-dimensional volumetric data set consisting of 195 en face planes. The TRBF was calculated from the maximum flow values of each branching retinal vein at an optimised en face plane. DR severity was graded according to the international clinical classification system. The generalised linear model method was used to compare flow values between DR groups and the control group. A total of 71 eyes from 71 participants were included. Ten eyes were excluded due to poor image quality. The within-visit repeatability of scans was 4.1% (coefficient of variation). There was no significant difference in the TRBF between the healthy (46.7±10.2 µL/min) and mild/moderate non-proliferative DR (44.9±12.6 µL/min) groups. The TRBF in severe non-proliferative DR (39.1±12.6 µL/min) and proliferative DR (28.9±8.85 µL/min) groups were significantly lower (p=0.04 and p<0.0001, respectively) than that of the healthy group. TRBF...Continue Reading

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Citations

Sep 22, 2017·Japanese Journal of Ophthalmology·Tadashi MatsumotoYuichi Hori
Oct 30, 2018·Investigative Ophthalmology & Visual Science·Yen-Lin ChenTravis W Hein
May 9, 2019·Biomedical Optics Express·Tristan T HormelYali Jia
Aug 25, 2020·Translational Vision Science & Technology·Stephan SzegediLeopold Schmetterer
Oct 28, 2020·Advances in Therapy·Anastasios G KonstasL Jay Katz

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