Assessment and Interpretation of Vitamin and Trace Element Status in Sick Children. A Position Paper from the ESPGHAN Committee in Nutrition

Journal of Pediatric Gastroenterology and Nutrition
Konstantinos GerasimidisESPGHAN Committee on Nutrition

Abstract

Assessment of vitamin and trace element status (VTE) is important in the clinical management of the sick child. In this position paper we present the various assessment methods available to the clinical practitioner, and critically discuss pitfalls with interpretation of their results.There are four main approaches to assess the VTE body status of an individual patient including clinical examination, dietary assessment and measurement of direct and indirect biomarkers of VTE in biological samples. Clinical signs of VTE deficiencies usually present only when body stores are substantially depleted and are often difficult to detect or differentiate from other non-nutrient related causes. In isolation, dietary assessment of micronutrients can be inaccurate and imprecise, in disease and in individual patient assessment, but may be useful to complement findings from other VTE assessment methods. Use of biomarkers is the most common approach to assess VTE status in routine practice, but in the presence of systemic inflammatory response and in the absence of appropriate paediatric reference intervals, interpretation of biomarker results might be challenging and potentially mislead clinical practice.The use of a multimodal approach, inc...Continue Reading

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Citations

Aug 9, 2020·JPEN. Journal of Parenteral and Enteral Nutrition·Gil HardyPatrick A Ball
Sep 14, 2020·Journal of Renal Nutrition : the Official Journal of the Council on Renal Nutrition of the National Kidney Foundation·Jetta TuokkolaTuula Hölttä
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May 1, 2021·Nutrients·Miguel A Montoro-HuguetManuel Domínguez-Cajal
May 3, 2021·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Lorcan McGroganKonstantinos Gerasimidis
May 9, 2021·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Raquel Revuelta IniestaDavid C Wilson
May 23, 2021·Archives of Disease in Childhood. Education and Practice Edition·Nicholas D Embleton
May 25, 2021·Clinical Nutrition ESPEN·Iva HojsakKoen Joosten
Jul 3, 2021·Nutrients·Teresa Di ChioOsvaldo Borrelli
Jul 27, 2021·Annals of the New York Academy of Sciences·Benjamin RakotoambininaFilomena Gomes
Aug 2, 2021·Pediatric Research·Eric L WaldL Nelson Sanchez-Pinto
Apr 20, 2021·Journal of Pediatric Gastroenterology and Nutrition·Elvira Verduci, Jutta Köglmeier

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