Assessment and Management of Neuropsychiatric Symptoms in Parkinson's Disease

CNS Drugs
Christoph MuellerDag Aarsland

Abstract

Neuropsychiatric symptoms are highly prevalent in Parkinson's disease and associated with decreased quality of life and adverse health outcomes. In this review, the assessment and management of common neuropsychiatric symptoms are discussed: depression, anxiety, psychosis, cognitive impairment, dementia and apathy. Validated assessment scales are now available for the majority of symptoms. Balancing dopaminergic therapy plays an important role in their management as increasing doses of dopaminergic agents might address depression and anxiety related to 'off' phases, non-motor fluctuations and apathy, while dose reduction might alleviate psychotic symptoms. More targeted treatment is possible through medications utilising different pathways. Although efficacy profiles of individual agents require further exploration, antidepressants as a drug class have shown utility in depression and anxiety in Parkinson's disease. Psychological therapies, especially cognitive behavioural approaches, are effective. Pimavanserin allows the treatment of psychosis in Parkinson's disease without directly affecting the dopaminergic and cholinergic system. The cholinergic system is currently the only target in Parkinson's disease dementia, and antago...Continue Reading

References

Apr 1, 1979·The British Journal of Psychiatry : the Journal of Mental Science·S A Montgomery, M Asberg
Nov 1, 1975·Journal of Psychiatric Research·M F FolsteinP R McHugh
Jan 1, 1992·The Journal of Neuropsychiatry and Clinical Neurosciences·S E StarksteinR G Robinson
Aug 1, 1991·Psychiatry Research·R S MarinS Firinciogullari
Apr 1, 1986·Journal of Neurology, Neurosurgery, and Psychiatry·A M GothamC D Marsden
Jan 1, 1982·Journal of Psychiatric Research·J A YesavageV O Leirer
Mar 11, 1999·The New England Journal of Medicine·UNKNOWN Parkinson Study Group
Sep 16, 1999·Journal of Neurology, Neurosurgery, and Psychiatry·D AarslandJ L Cummings
Sep 18, 1999·International Journal of Geriatric Psychiatry·M Hopman-RockR M Dröes
Jun 8, 2001·Movement Disorders : Official Journal of the Movement Disorder Society·L M ShulmanW J Weiner
Nov 6, 2002·Neuropsychologia·V CzerneckiB Dubois
Nov 12, 2002·The Journal of Neuropsychiatry and Clinical Neurosciences·Anjan Chatterjee, Stanley Fahn
Mar 14, 2003·Archives of Neurology·Dag AarslandPer Kragh-Sørensen
Aug 2, 2003·Biological Psychiatry·William M McDonaldMahlon R DeLong
Jun 1, 1961·Archives of General Psychiatry·A T BECKJ ERBAUGH
Feb 1, 1960·Journal of Neurology, Neurosurgery, and Psychiatry·M HAMILTON
Oct 14, 2004·International Journal of Geriatric Psychiatry·Antonios M PolitisConstantine G Lyketsos
Dec 14, 2004·The New England Journal of Medicine·Murat EmreRoger Lane
Dec 18, 2004·Journal of Speech, Language, and Hearing Research : JSLHR·Sandra Bond ChapmanJennifer Zientz
Mar 31, 2005·International Journal of Geriatric Psychiatry·Renate VerkaikAnneke L Francke
Apr 1, 2005·Movement Disorders : Official Journal of the Movement Disorder Society·William G OndoGeorge Ringholz
Apr 9, 2005·Journal of the American Geriatrics Society·Ziad S NasreddineHoward Chertkow
Jun 9, 2005·The Journal of Neuropsychiatry and Clinical Neurosciences·Matthias R LemkeHeinz Reichmann
Oct 8, 2005·Movement Disorders : Official Journal of the Movement Disorder Society·Laura MarshUNKNOWN NINDS/NIMH Work Group on Depression and Parkinson's Disease
Apr 12, 2006·Journal of Neurology·Paolo BaroneUNKNOWN Depression/Parkinson Italian Study Group
Apr 15, 2006·Journal of Neurology, Neurosurgery, and Psychiatry·P SockeelL Defebvre
Jun 30, 2006·International Psychogeriatrics·Nancy A PachanaElizabeth Arnold
Jun 30, 2006·International Psychogeriatrics·Clive HolmesVivienne Hopkins
Sep 9, 2006·Movement Disorders : Official Journal of the Movement Disorder Society·David BurnRoger Lane
Sep 16, 2006·International Journal of Geriatric Psychiatry·Eneida MioshiJohn R Hodges
Jan 19, 2007·Movement Disorders : Official Journal of the Movement Disorder Society·Angelika Nebe, Georg Ebersbach
Feb 3, 2007·Movement Disorders : Official Journal of the Movement Disorder Society·Bernard RavinaChristopher Goetz
Mar 31, 2007·Movement Disorders : Official Journal of the Movement Disorder Society·Anette SchragChristopher G Goetz
Apr 25, 2007·Neurology·Roger KurlanUNKNOWN Alzheimer's Disease Cooperative Study Group
Apr 26, 2007·Neuroscience and Behavioral Physiology·O S Levin
Jun 2, 2007·Movement Disorders : Official Journal of the Movement Disorder Society·Murat EmreBruno Dubois
Jun 5, 2007·Alzheimer Disease and Associated Disorders·Fredrik BoströmElisabet Londos
Aug 4, 2007·Movement Disorders : Official Journal of the Movement Disorder Society·Kallol Ray ChaudhuriAnthony H V Schapira
Nov 8, 2007·Movement Disorders : Official Journal of the Movement Disorder Society·Jennifer S A M ReijndersAlbert F G Leentjens
Nov 16, 2007·Journal of Geriatric Psychiatry and Neurology·Sara L Wright, Carol Persad
Mar 4, 2008·Movement Disorders : Official Journal of the Movement Disorder Society·David DevosLuc Defebvre
Apr 3, 2008·Movement Disorders : Official Journal of the Movement Disorder Society·Javier PagonabarragaAlexandre Gironell

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Citations

Mar 28, 2020·Journal of Neurology, Neurosurgery, and Psychiatry·John O'BrienDominic Ffytche
Sep 2, 2020·International Journal of Geriatric Psychiatry·Catherine PenningtonCraig Ritchie
Jul 10, 2019·Parkinson's Disease·Kristina RosqvistPer Odin
Feb 11, 2020·Frontiers in Pharmacology·Anamaria BogdanRenaud David
Jan 5, 2021·Frontiers in Neurology·Xin-Yue ZhouYi-Min Sun
Jan 20, 2021·Journal of Geriatric Psychiatry and Neurology·Karun BadwalSandeep R Pagali
May 7, 2021·Journal of the American Medical Directors Association·Chien-Tai HongTsai-Wei Huang
Aug 19, 2021·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Xiaoxue ShiShiyu Hu
Nov 30, 2021·Fortschritte der Neurologie-Psychiatrie·Daniel WeissHeinz Reichmann

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