Assessment and Transplantation of Orphan Donor Livers: A Back-to-Base Approach to Normothermic Machine Perfusion.

Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society
Janske ReilingJonathan Fawcett

Abstract

Globally, a large proportion of donor livers are discarded due to concerns over inadequate organ quality. Normothermic machine perfusion (NMP) allows for hepatocellular and biliary viability assessment prior to transplantation and might therefore enable the safe use of these orphan donor livers. We describe here the first Australasian experience of NMP-preserved liver transplants using a 'back-to-base' approach, where NMP was commenced at the recipient hospital following initial static cold storage. In the preclinical phase, 10 human donor livers declined for transplantation (7 from donation after circulatory death [DCD] and 3 from donation after brain death [DBD]) were perfused using a custom-made NMP setup. Subsequently, 10 orphan donor livers (5 from DCD and 5 from DBD) underwent NMP and viability assessment on the OrganOx metra device (OrganOx Limited, Oxford, United Kingdom). Both hepatocellular and biliary viability criteria were used. The median donor risk index was 1.53 (1.16-1.71), and the median recipient Model for End-Stage Liver Disease score was 17 (11-21). In the preclinical phase, 'back-to-base' NMP was deemed suitable and feasible. In the clinical phase, each graft met predefined criteria for implantation during...Continue Reading

References

Dec 26, 2001·Transplantation Proceedings·P J FriendM A Rees
Apr 15, 2003·Journal of the American College of Surgeons·James F MarkmannRonald W Busuttil
Aug 3, 2010·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Kim M OlthoffJason D Christie
Mar 8, 2013·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·S op den DriesR J Porte
Jul 25, 2013·The Medical Journal of Australia·Jorieke M van der SteltMichael Crawford
Feb 19, 2015·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Janske ReilingJonathan Fawcett
Jan 12, 2016·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·R RavikumarP J Friend
May 1, 2016·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·S A KarangwaR J Porte
Oct 28, 2016·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·H MergentalD F Mirza
Oct 27, 2016·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Markus SelznerDavid R Grant
Oct 22, 2016·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·M BralA M J Shapiro
Jun 25, 2017·Biochimica Et Biophysica Acta. Molecular Basis of Disease·Yvonne de VriesRobert J Porte
Feb 9, 2018·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Christopher J E WatsonAndrew J Butler
Mar 15, 2018·Transplantation Direct·Janske ReilingJonathan Fawcett
Apr 20, 2018·Nature·David NasrallaUNKNOWN Consortium for Organ Preservation in Europe
Oct 26, 2018·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Hynek MergentalSimon C Afford
Dec 19, 2018·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Wayel JassemYun Ma
Apr 3, 2019·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Mariusz BralA M James Shapiro
Jun 18, 2019·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Carlo D L CeresaPeter J Friend
Jan 15, 2020·Nature Biotechnology·Dilmurodjon EshmuminovPierre-Alain Clavien

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Citations

Aug 23, 2020·International Journal of Molecular Sciences·Raji BaidyaKim R Bridle
Oct 9, 2020·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Joy V Nolte FongR Mark Ghobrial
Mar 3, 2021·Current Opinion in Organ Transplantation·Hanns Lembach JahnsenDarius F Mirza
Sep 18, 2020·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Angus HannM Thamara P R Perera
May 27, 2021·Transplantation Direct·Amanda LiesegangPeter Hodgkinson
Nov 11, 2021·American Journal of Physiology. Gastrointestinal and Liver Physiology·Bianca LascarisVincent E de Meijer
Nov 19, 2021·The British Journal of Surgery·Belle LiewDimitri A Raptis

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