Assessment and treatment of airflow obstruction in patients with chronic obstructive pulmonary disorder: a guide for the clinician.

Expert Review of Respiratory Medicine
Claudio Tantucci

Abstract

Introduction: Chronic obstructive pulmonary disorder (COPD) is a common cause of disability, morbidity and mortality worldwide. Early diagnosis and adequate treatment maintained over time are crucial to reducing these harmful consequences.Areas covered Persistent, not reversible and naturally progressive airflow obstruction is the functional hallmark of COPD. Therefore, in the presence of individual and environmental risk factors, with or without reported suggestive symptoms, simple spirometry must be performed enough quickly to objectify an obstructive ventilatory defect and assist physicians in making a diagnosis of COPD. Then, to cope with the heterogeneity of COPD patients, more specific functional tests and imaging techniques should be implemented to better define the underlying prevalent disease and its severity. That is necessary to decide whether to introduce ICS and establish the initial level of the treatment with just one or two bronchodilators, to control and freeze, when possible, the underlying pathological process.Expert opinion: The objective assessment of airflow obstruction is mandatory to make a diagnosis of COPD, but the prevalent disease sustaining the disorder should also be investigated to select a target...Continue Reading

References

Dec 1, 1991·The American Review of Respiratory Disease·W D KimM G Cosio
Jun 20, 1968·The New England Journal of Medicine·J C HoggW M Thurlbeck
Feb 1, 1995·The European Respiratory Journal·N G KoulourisJ Milic-Emili
Dec 1, 1996·American Journal of Respiratory and Critical Care Medicine·L EltayaraJ Milic-Emili
Mar 1, 1997·Journal of Applied Physiology·N G KoulourisJ Milic-Emili
Nov 17, 1998·The European Respiratory Journal·C TantucciJ Milic-Emili
Jun 14, 2000·Journal of Applied Physiology·I CerveriV Brusasco
Jan 3, 2001·American Journal of Physiology. Lung Cellular and Molecular Physiology·K TakeyamaJ A Nadel
May 24, 2001·American Journal of Respiratory and Critical Care Medicine·V NinaneR Sergysels
Sep 11, 2001·American Journal of Respiratory and Critical Care Medicine·D E O'DonnellK A Webb
Nov 12, 2002·American Journal of Respiratory and Critical Care Medicine·Leonardo M FabbriAlberto Papi
May 22, 2003·The New England Journal of Medicine·Alfred FishmanUNKNOWN National Emphysema Treatment Trial Research Group
Jun 20, 2003·Respiratory Medicine·B SitkauskieneJ Lötvall
Feb 26, 2004·The European Respiratory Journal·R L DellacàP M A Calverley
Mar 5, 2004·The New England Journal of Medicine·Bartolome R CelliHoward J Cabral
Jun 25, 2004·The New England Journal of Medicine·James C HoggPeter D Paré
Jan 11, 2005·The European Respiratory Journal·P M A Calverley, N G Koulouris
Aug 2, 2005·The European Respiratory Journal·M R MillerUNKNOWN ATS/ERS Task Force
Nov 3, 2005·The European Respiratory Journal·R PellegrinoJ Wanger
Mar 28, 2006·Proceedings of the American Thoracic Society·Denis E O'Donnell
Aug 6, 2008·Journal of Applied Physiology·Denis E O'Donnell, Katherine A Webb
Jul 24, 2010·Journal of Applied Physiology·Simonetta BaldiRiccardo Pellegrino
Sep 24, 2010·The New England Journal of Medicine·Frank C SciurbaUNKNOWN VENT Study Research Group
Mar 4, 2011·Respiratory Medicine·Sabina M JanciauskieneTobias Welte
Aug 23, 2011·International Journal of Chronic Obstructive Pulmonary Disease·Bernard M FischerJudith A Voynow
Oct 28, 2011·The New England Journal of Medicine·John E McDonoughJames C Hogg
Jan 28, 2012·The European Respiratory Journal·Felix J F HerthUNKNOWN International VENT Study Group
Mar 1, 2012·International Journal of Chronic Obstructive Pulmonary Disease·Claudio Tantucci, Denise Modina
May 9, 2012·American Journal of Respiratory and Critical Care Medicine·Miguel DivoUNKNOWN BODE Collaborative Group
May 25, 2012·PloS One·Alvar AgustíUNKNOWN Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints (ECLIPSE) Investigators
Jul 28, 2012·The European Respiratory Journal·Jadwiga A WedzichaTerence A R Seemungal
Jul 9, 2013·Translational Research : the Journal of Laboratory and Clinical Medicine·Marco ChilosiVenerino Poletti
Jul 13, 2013·The European Respiratory Journal·Arschang ValipourUNKNOWN VENT Study Group
Oct 9, 2014·Annals of the American Thoracic Society·Brian D HobbsUNKNOWN COPDGene Investigators
Dec 30, 2014·The European Respiratory Journal·Pierre ErnstSamy Suissa

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