Assessment by autonomic blockade of age-related changes of the sinus node function and autonomic regulation in sick sinus syndrome

The American Journal of Cardiology
K KugaI Ito

Abstract

Age-related changes of the sinus node (SN) function and the autonomic influence on the SN function were evaluated in 65 patients with sick sinus syndrome (range 14 to 84 years). Heart rate (HR), corrected SN recovery time and sinoatrial conduction time were measured before (basic) and after (intrinsic) autonomic blockade (propranolol 0.2 mg/kg plus atropine 0.04 mg/kg intravenously). Percent of autonomic chronotropies of the SN function were calculated by the following formulas: (1)--(intrinsic HR--basic HR/intrinsic HR) X 100; (2) (intrinsic corrected SN recovery time--basic corrected SN recovery time/intrinsic corrected SN recovery time) X 100; (3) (intrinsic sinoatrial conduction time--basic sinoatrial conduction time/intrinsic sinoatrial conduction time) X 100. Basic HR, basic corrected SN recovery time and basic sinoatrial conduction time did not vary with age. Intrinsic HR decreased with age, but this correlation was weak (r = -0.54, p less than 0.001). Intrinsic corrected SN recovery time and intrinsic sinoatrial conduction time tended to increase with age (r = 0.26, p less than 0.05; r = 0.29, p less than 0.05, respectively). Percent chronotropies of HR, corrected SN recovery time and sinoatrial conduction time were neg...Continue Reading

References

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Citations

May 1, 1994·Journal of Clinical Pharmacology·M A FreyW G Hoffler
Nov 30, 2000·Current Treatment Options in Cardiovascular Medicine·W J MandelH S Karagueuzian
Jan 17, 2012·Clinical Cardiology·Nihar R Desai, Robert P Giugliano

Related Concepts

Teens
Age Factors
Atropine Sulfate Anhydrous
Sympathetic Nerve Block
Autonomic Nervous System
Cardiac Pacing, Artificial
Electrophysiology (Science)
Pulse Rate
Rexigen
Sinus Node Dysfunction (Disorder)

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