PMID: 2359Dec 1, 1975

Assessment in the guinea-pig ileum and mouse vas deferens of benzomorphans which have strong antinociceptive activity but do not substitute for morphine in the dependent monkey

British Journal of Pharmacology
M HutchinsonA A Waterfield

Abstract

1 Four benzomorphans which have potent antinociceptive activity in the hot-plate and writhing tests in the mouse but do not suppress or precipitate withdrawal symptoms in the morphine-dependent monkey, have been examined for their pharmacological actions in the guinea-pig ileum and mouse vas deferens. 2 In the guinea-pig ileum their agonist potencies are 1.5 to 400 times greater than that of normorphine of morphine whereas in the mouse vas deferens their potencies relative to morphine are 0.3 to 100. They exhibit no antagonist activity in either preparation. Benzomorphans which substitute for morphine in the morphine-dependent monkey do not show such differences between their relative potencies in the guinea-pig ileum and mouse vas diferens. 3 The relative potencies of the four benzomorphans to inhibit stereospecific [3H]-dihydromorphine binding by membrane fragments from rat brain, are more closely related to their relative agonist potencies in the mouse vas deferens than to those found in the guinea-pig ileum. 4 In order to antagonize the agonist actions of these benzomorphans, naloxone is required in concentrations which are 3 to 7 times higher than those needed for the antagonism of normorphine or morphine or of benzomorpha...Continue Reading

References

Jan 1, 1975·Annual Review of Pharmacology·H W Kosterlitz, A A Waterfield
Jul 1, 1975·Life Sciences·H W Kosterlitz, J Hughes
Jan 1, 1975·British Journal of Pharmacology·H W Kosterlitz, A A Waterfield
Feb 1, 1974·The Journal of Pharmacy and Pharmacology·L Terenius
Aug 1, 1973·Proceedings of the National Academy of Sciences of the United States of America·C B Pert, S H Snyder
Aug 1, 1971·Proceedings of the National Academy of Sciences of the United States of America·A GoldsteinB K Pal
Jun 1, 1968·British Journal of Pharmacology and Chemotherapy·H W Kosterlitz, A J Watt

Citations

Oct 1, 1987·Naunyn-Schmiedeberg's Archives of Pharmacology·S M JohnsonR Shearman
Jun 1, 1982·Naunyn-Schmiedeberg's Archives of Pharmacology·J MagnanH W Kosterlitz
Aug 1, 1986·Naunyn-Schmiedeberg's Archives of Pharmacology·L A Chahl
Jan 1, 1981·Naunyn-Schmiedeberg's Archives of Pharmacology·U Havemann, K Kuschinsky
Nov 7, 1980·European Journal of Pharmacology·J J Teal, S G Holtzman
Aug 22, 1980·European Journal of Pharmacology·D W Harris, V H Sethy
Nov 21, 1980·European Journal of Pharmacology·Y AudigierJ Cros
Nov 19, 1981·European Journal of Pharmacology·R Schulz, M Wüster
Apr 9, 1981·European Journal of Pharmacology·B K HandaC F Smith
Jul 10, 1981·European Journal of Pharmacology·Y ItzhakS Cohen
Oct 15, 1982·European Journal of Pharmacology·R SchulzA Herz
Jul 9, 1982·European Journal of Pharmacology·J F Kachur, R J Miller
Nov 19, 1982·European Journal of Pharmacology·S J WardA E Takemori
Jan 21, 1983·European Journal of Pharmacology·H H Osborne, A Herz
Oct 14, 1983·European Journal of Pharmacology·L A Dykstra
Jan 15, 1985·European Journal of Pharmacology·H C Moises, J M Walker
Apr 16, 1985·European Journal of Pharmacology·A G Hayes, A Kelly
May 7, 1987·European Journal of Pharmacology·J R TraynorH W Kosterlitz
Dec 7, 1989·European Journal of Pharmacology·K G MeechamJ Hughes
Jul 4, 1989·European Journal of Pharmacology·S GrellJ D Christensen
Apr 10, 1990·European Journal of Pharmacology·F PorrecaS J Ward
Jun 21, 1990·European Journal of Pharmacology·V U DissanayakeJ Hughes
Jan 10, 1991·European Journal of Pharmacology·N P Pillai, S M Johnson
Oct 3, 1996·European Journal of Pharmacology·S KatsumataM Satoh
Aug 1, 1979·Neuropharmacology·T H LanthornR L Isaacson
Aug 1, 1988·Pharmacology, Biochemistry, and Behavior·K M KumorR E Johnson
Jan 1, 1996·Pharmacology & Therapeutics·A De Luca, I M Coupar
Jan 1, 1980·Peptides·S L Dickinson, P Slater
Aug 5, 1999·British Journal of Pharmacology·L RomanelliP Valeri
May 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·J F KachurM Field
Aug 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·K J ChangP Cuatrecasas
Feb 1, 1994·Journal of Autonomic Pharmacology·I M Coupar, A De Luca
Sep 1, 1990·British Journal of Pharmacology·J C HunterJ Hughes
Oct 1, 1994·The Journal of Pharmacy and Pharmacology·D L Hancock, I M Coupar
Aug 1, 1995·The Journal of Pharmacy and Pharmacology·I M Coupar
Aug 15, 1986·Science·A PfeifferH M Emrich
Nov 24, 2011·World Journal of Gastroenterology : WJG·Krishan KumarSantosh Pasha
Jan 1, 1978·Drug Metabolism Reviews·T T Chau-Pham
Jan 8, 2016·Annual Review of Pharmacology and Toxicology·Sonia PodvinVivian Hook
May 1, 1988·The Journal of Pharmacy and Pharmacology·J M Coupar, M J Quinn
Aug 1, 1981·British Journal of Pharmacology·H W KosterlitzL E Robson
Mar 1, 1986·British Journal of Pharmacology·L MillerE M Whiting
Mar 1, 1988·British Journal of Pharmacology·C R ClarkJ Hughes
Nov 1, 1980·British Journal of Pharmacology·M G GillanS J Paterson
Jul 1, 1980·British Journal of Pharmacology·M B Tyers
Mar 15, 2003·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Carrie A BowenNancy K Mello
Jan 1, 1981·Medicinal Research Reviews·E T Iwamoto, W R Martin
Jun 9, 1977·Nature·J A LordH W Kosterlitz
Jan 1, 1982·Annals of the New York Academy of Sciences·S G Holtzman
Feb 1, 1985·Acta Pharmacologica Et Toxicologica·A Neil
Mar 1, 1977·British Journal of Pharmacology·K G GreinerJ R Wood
Oct 1, 1988·Pharmacology & Toxicology·S GrellB Fjalland
Jul 12, 2005·CNS Drug Reviews·Juanita Dortch-Carnes, David E Potter

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Opioids
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Benzomorphan
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