PMID: 2485272Jun 1, 1985Paper

Assessment in vitro and in vivo of muscle degradation in chronic skeletal muscle myopathy of alcoholism

Clinical Science
F C Martin, T J Peters

Abstract

1. Muscle protein breakdown in vivo has been studied by measurements of urinary 3-methyl-histidine/creatinine ratios. No differences were found between control subjects and chronic alcoholics either with or without proximal muscle wasting or cirrhosis. 2. Calculation of muscle turnover rates, with the correction of Afting et al. (1981, Biochemical Journal, 200, 449-452) for non-skeletal muscle contributions of 3-methylhistidine and creatinine, showed lower values for alcoholics compared with controls. 3. Tissue activities of a neutral protease, assayed by a novel, rapid and sensitive fluorimetric method, were similar in patients and controls. The activity did not vary with severity of atrophy or the presence of cirrhosis. 4. No evidence was therefore obtained to suggest that alcoholic myopathy is due to increased muscle breakdown.

Citations

Oct 19, 2004·Muscle & Nerve·Alvaro Urbano-Márquez, Joaquim Fernández-Solà
Oct 6, 2009·Toxicology in Vitro : an International Journal Published in Association with BIBRA·David B OwenWade A Grow
May 1, 1989·Metabolism: Clinical and Experimental·H P PetersJ W Elvers
Feb 5, 2014·Autophagy·Samjhana ThapaliyaSrinivasan Dasarathy
Jan 11, 2002·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·V R PreedyT J Peters
Aug 22, 2018·Annual Review of Nutrition·Scot R Kimball, Charles H Lang
Jun 8, 2001·Alcoholism, Clinical and Experimental Research·C C CunninghamK Torii
Oct 1, 1995·Alcoholism, Clinical and Experimental Research·X XuW E Sonntag
Oct 5, 2001·Alcoholism, Clinical and Experimental Research·L Q Hong-BrownC H Lang
Feb 1, 2007·American Journal of Physiology. Endocrinology and Metabolism·Charles H LangThomas C Vary
Apr 11, 2008·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Thomas C VaryCharles H Lang
Mar 29, 2014·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Liz SimonPatricia E Molina
Mar 12, 2015·American Journal of Physiology. Endocrinology and Metabolism·Jennifer L Steiner, Charles H Lang
Mar 18, 2015·Physiological Reports·Jennifer L SteinerCharles H Lang
May 2, 2001·The International Journal of Biochemistry & Cell Biology·C H LangT C Vary

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