Assessment of 123 I-mIBG and 99m Tc-tetrofosmin single-photon emission computed tomographic images for the prediction of arrhythmic events in patients with ischemic heart failure: Intermediate severity innervation defects are associated with higher arrhythmic risk

Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology
Mark I TravinHein J Verberne

Abstract

123I-mIBG planar image heart-to-mediastinum ratios effectively risk-stratify heart failure (HF) patients. The value of single-photon emission computed tomographic (SPECT) imaging for identifying increased risk of ventricular arrhythmias is less clear. This study sought to determine if findings from simultaneous interpretation of 123I-mIBG and 99mTc-tetrofosmin SPECT are predictive of arrhythmic events (ArEs). 123I-mIBG SPECT images from 622 patients with ischemic HF were presented in standard displays alongside 99mTc-tetrofosmin images. Consensus interpretations using a 17-segment model produced summed scores. Cox proportional hazards analyses related findings to adjudicated ArEs over 2 years. 471 patients had images adequate for total 17-segment scoring. There were 48 ArEs (10.2%). Neither 123I-mIBG nor 99mTc-tetrofosmin SPECT summed scores were univariate predictors. On multivariate proportional hazards analysis, the 123I-mIBG SPECT score was independently predictive of ArEs (HR: 0.975, 95% CI 0.951-0.999, P = 0.042), but HR<1 indicated that risk decreased with increasing score. This occurred because patients with intermediately abnormal SPECT studies had a higher likelihood of ArEs compared to patients with extensive abnorma...Continue Reading

References

Nov 24, 1998·Circulation·D P Zipes, H J Wellens
Dec 30, 1998·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·T NakataK Shimamoto
Apr 4, 2003·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Rishi AroraMark I Travin
Apr 4, 2006·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Ji ChenIgnasi Carrio
Apr 14, 2006·European Journal of Nuclear Medicine and Molecular Imaging·Matthias PaulThomas Wichter
Aug 7, 2007·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Ernest V GarciaCesar Santana
Jun 7, 2008·Journal of the American College of Cardiology·Tetsuo SasanoFrank M Bengel
Jan 20, 2009·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Arnold F JacobsonPaolo G Camici
Jun 17, 2010·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Thomas A HollyUNKNOWN American Society of Nuclear Cardiology
Aug 2, 2011·Seminars in Nuclear Medicine·Amala Chirumamilla, Mark I Travin
Mar 14, 2013·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Arnold F JacobsonErnest V Garcia
Oct 1, 2013·Journal of the American College of Cardiology·James A FallavollitaJohn M Canty
Jun 13, 2015·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Jagat NarulaArnold F Jacobson

❮ Previous
Next ❯

Citations

Sep 20, 2017·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Kenichi NakajimaHein J Verberne
Feb 8, 2018·European Heart Journal Cardiovascular Imaging·Kenichi NakajimaArnold F Jacobson
Sep 21, 2019·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·H J Verberne, D O Verschure
Sep 30, 2016·Netherlands Heart Journal : Monthly Journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation·D O VerschureH J Verberne
Jan 14, 2017·Current Cardiology Reports·Mark I Travin
Nov 10, 2017·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Wael A AlJaroudi, Fadi G Hage
Mar 30, 2018·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Giuseppe De VincentisHein J Verberne
Jul 7, 2017·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Mark I Travin
Jun 10, 2017·Clinical and Translational Imaging : Reviews in Nuclear Medicine and Molecular Imaging·Kenichi NakajimaHein J Verberne
Aug 28, 2020·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Svetlana I SazonovaSergey V Popov
Nov 29, 2017·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Yusuke TokudaHiroyuki Tsutsui
May 16, 2020·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Kenichi NakajimaKoji Maruyama
Oct 20, 2017·European Journal of Nuclear Medicine and Molecular Imaging·Federico Caobelli
Apr 27, 2018·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Anna Teresińska
Oct 22, 2020·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Mark I Travin
Jan 15, 2021·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Mariano PonticoGiuseppe De Vincentis
Sep 17, 2017·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Raza AlviYi-Hwa Liu

❮ Previous
Next ❯

Related Concepts

Related Feeds

Atrial Fibrillation

Atrial fibrillation is a common arrhythmia that is associated with substantial morbidity and mortality, particularly due to stroke and thromboembolism. Here is the latest research.

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.

Brain Ischemia

Brain ischemia is a condition in which there is insufficient blood flow to the brain to meet metabolic demand. Discover the latest research on brain ischemia here.

© 2022 Meta ULC. All rights reserved