Assessment of a Chemotherapy Response Score (CRS) System for Tubo-Ovarian High-Grade Serous Carcinoma (HGSC)

International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists
Helena M DitzelBrooke E Howitt

Abstract

A chemotherapy response score (CRS) system was recently described to assess the histopathologic response and prognosis of patients with tubo-ovarian high-grade serous carcinoma (HGSC) receiving neoadjuvant chemotherapy. The current study was performed as an independent assessment of this CRS system. We retrospectively identified advanced stage HGSC patients who received neoadjuvant chemotherapy and underwent interval debulking. If available, a hemotoxylin and eosin slide from the omentum and the adnexa was selected for the study. Slides were independently scored by 13 pathologists using the 3-tiered CRS system. Reviewers then received web-based training and rescored the slides. Overall survival and progression-free survival were estimated using the Kaplan-Meier method and compared using the log-rank test. A total of 68 patients with omental (n=65) and/or adnexal (n=59) slides were included in the study. Interobserver reproducibility was moderate for omentum (κ, 0.48) and poor for adnexa (κ, 0.40), which improved for omentum (κ, 0.62) but not for adnexa (κ, 0.38) after online training. For omental slides, a consensus CRS of 1/2 was associated with a shorter median progression-free survival (10.9 mo; 95% confidence interval, 9-14...Continue Reading

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Citations

May 3, 2019·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·N ColomboUNKNOWN ESMO–ESGO Ovarian Cancer Consensus Conference Working Group
Oct 28, 2019·The American Journal of Surgical Pathology·Barrett C LawsonAnais Malpica
May 8, 2019·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Camilla NeroMarco Petrillo
Dec 18, 2019·Histopathology·Anthony T Williams, Raji Ganesan
Jan 27, 2019·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Steffen BöhmNaveena Singh
Nov 3, 2020·Critical Reviews in Oncology/hematology·Riccardo Ponzone
May 3, 2019·Annals of Oncology : Official Journal of the European Society for Medical Oncology·N ColomboUNKNOWN ESMO-ESGO Ovarian Cancer Consensus Conference Working Group
Jan 29, 2020·Annals of Oncology : Official Journal of the European Society for Medical Oncology·N ColomboUNKNOWN ESMO-ESGO Ovarian Cancer Consensus Conference Working Group
Apr 10, 2021·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Ina JaniKatherine C Kurnit
Sep 9, 2020·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Michelle HeaynRohit Bhargava
Jun 17, 2021·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Claudia MarchettiAnna Fagotti

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