Assessment of a point-of-care instrument for identification of primary hemostatic disorders in dogs

American Journal of Veterinary Research
Mary Beth Callan, Urs Giger

Abstract

To assess a point-of-care instrument for identification of primary hemostatic disorders in dogs. 29 healthy dogs and 23 nonanemic dogs with primary hemostatic disorders (thrombocytopenia, n = 6; thrombopathia, 6; von Willebrand disease [vWD], 11). Citrated blood was obtained and closure times (CT) were determined by measuring the time required for occlusion of an aperture by a platelet plug within the point-of-care instrument. Reference ranges for CT were established, and CT were determined for dogs with primary hemostatic disorders. CT measured with adenosine diphosphate as the platelet agonist (ADP-CT) ranged from 52 to 86 seconds for healthy dogs (mean +/- 2 SD, 67 +/- 7.8 seconds; median, 65 seconds), and CT measured with epinephrine as the agonist (EPI-CT), from 97 to 225 seconds (151 +/- 38 seconds; 148 seconds). In thrombocytopenic dogs, ADP- and EPI-CT were prolonged (> 165 and > 264 seconds, respectively). Five of 6 dogs with thrombopathia had prolonged ADP-CT, whereas EPI-CT was prolonged in all 6 dogs. In all dogs with vWD, ADP-CT was prolonged; EPI-CT was prolonged in 10 of these dogs. Sensitivity and specificity for ADP-CT were 95.7 and 100%, respectively, and positive and negative predictive values, 100 and 96.7%,...Continue Reading

References

Mar 1, 1992·British Journal of Anaesthesia·S W O'KellyJ B Luntley
Jan 1, 1990·Seminars in Thrombosis and Hemostasis·R P Rodgers, J Levin
Sep 17, 1994·The Veterinary Record·S J BrownC M Elwood
Mar 1, 1994·Journal of Veterinary Internal Medicine·M K BoudreauxM Toivio-Kinnucan
Feb 1, 1994·British Journal of Haematology·M A BlajchmanN M Heddle
Sep 1, 1997·Journal of the American Animal Hospital Association·L E SmedileG P Searcy
May 14, 1998·Seminars in Thrombosis and Hemostasis·E F MammenD J Nugent
Mar 10, 1999·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·P HarrisonS J Machin
May 18, 2001·Veterinary Pathology·M K Boudreaux, D L Lipscomb
May 22, 2001·Journal of the American Animal Hospital Association·M B CallanU Giger

❮ Previous
Next ❯

Citations

Sep 7, 2007·Veterinary Clinical Pathology·Line A NielsenInge Tarnow
Apr 28, 2009·Veterinary Clinical Pathology·Noel ClanceyEtienne Côté
Jun 25, 2009·Veterinary Clinical Pathology·Noel ClanceyEtienne Côté
Oct 31, 2012·Journal of Veterinary Internal Medicine·J ThomasonA Mackin
Jun 14, 2013·BMC Veterinary Research·Annika FerkauGregor Theilmeier
Jan 6, 2005·American Journal of Veterinary Research·Inge TarnowHenrik D Pedersen
Apr 4, 2006·American Journal of Veterinary Research·Jinelle A WebbPatricia A Gentry
Jun 5, 2007·American Journal of Veterinary Research·Janelle R WierengaFern Tablin
Nov 28, 2012·American Journal of Veterinary Research·Janine ClassenKatrin Hartmann
Jul 25, 2013·American Journal of Veterinary Research·Duana McBrideLisa Smart
Apr 29, 2004·Journal of the American Veterinary Medical Association·Chick WeisseJeffrey A Solomon
Oct 31, 2014·Journal of the American Veterinary Medical Association·Lyndsay R KongMarc P Dhumeaux
Oct 23, 2013·The Veterinary Clinics of North America. Small Animal Practice·Marjory B Brooks, James L Catalfamo
Oct 4, 2012·Topics in Companion Animal Medicine·Jennifer Herring, Maureen McMichael
Jul 16, 2011·The Veterinary Clinics of North America. Small Animal Practice·Benjamin M Brainard, Andrew J Brown
Jun 29, 2010·The Veterinary Journal·K KalbantnerR Mischke
Apr 6, 2007·The Veterinary Journal·Giuseppe PiccioneElisabetta Giudice
Oct 8, 2003·Journal of Veterinary Internal Medicine·Inge TarnowHenrik D Pedersen
Oct 14, 2009·Journal of Veterinary Emergency and Critical Care·Lisa SmartFern Tablin
Jan 18, 2012·Veterinary Anaesthesia and Analgesia·Kathleen B MullinsAndrew J Mackin
Sep 29, 2012·Journal of Veterinary Emergency and Critical Care·Bo WiinbergAnnemarie T Kristensen
Jan 3, 2013·Journal of Veterinary Internal Medicine·A DudleyK Lunsford
Jul 22, 2014·Journal of Veterinary Emergency and Critical Care·Kim A HelmboldSteven E Epstein
Oct 18, 2013·Veterinary Clinical Pathology·Marcel AumannArmelle Diquélou
Mar 31, 2016·American Journal of Veterinary Research·Jillian M HainesAndrew J Mackin
May 9, 2016·Journal of Veterinary Internal Medicine·J ThomasonA Mackin
Jul 28, 2016·Topics in Companion Animal Medicine·Clare E Hyatt, Benjamin M Brainard
Mar 13, 2016·Journal of Veterinary Pharmacology and Therapeutics·J ThomasonA Mackin
Jul 28, 2016·Journal of Veterinary Pharmacology and Therapeutics·B E ThamesJ Thomason
Jul 1, 2017·Journal of Veterinary Pharmacology and Therapeutics·N McLeweeJ Thomason
May 7, 2015·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·Kimberly K HoShauna L Blois
Jul 11, 2006·Journal of Gastroenterology and Hepatology·T G Himani FerdinandisH Janaka de Silva
Feb 8, 2019·The European Journal of Contraception & Reproductive Health Care : the Official Journal of the European Society of Contraception·Sofia HammarströmSusanne Bernhardsson
Mar 21, 2019·Ciência & saúde coletiva·Marcos Vinicius Ferreira Dos SantosSandra Lúcia Correia Lima Fortes
Dec 13, 2005·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Maruti Ram GudavalliAvinash G Patwardhan

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.