Assessment of a rapid clearance blood pool MR contrast medium (P792) for assays of microvascular characteristics in experimental breast tumors with correlations to histopathology

Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine
K TuretschekR C Brasch

Abstract

The diagnostic potential of a new rapid clearance blood pool contrast medium (P792; MW = 6.47 kDa) for the MR assessment of microvessel characteristics was assessed in 42 chemically-induced breast tumors, with comparisons to albumin-(Gd-DTPA). Microvessel characteristics, including the transendothelial permeability (K(PS)) and the fractional blood volume (fPV), were estimated by using dynamic MR data fit to a bidirectional two-compartment model. The MR-derived estimates for K(PS) and fPV using each contrast agent were compared, and assays using each contrast agent were correlated to the histologic tumor grade (SBR score) and the microvascular density (MVD) counts. Using P792-enhanced data, neither K(PS) nor fPV showed a statistically significant correlation with the tumor grade or the MVD (P >.05). Conversely, using albumin-(GdDTPA)(30), K(PS) values correlated significantly with the histologic tumor grade (r =.55; P <.0005) and the MVD (r =.34, P <.05), whereas no correlation was established for fPV. In conclusion, based on P792 data no correlation between tumor microvascular characteristics and histologic markers (SBR score or MVD) was found in this breast tumor model. Our analysis suggests that contrast media of relatively l...Continue Reading

References

Jan 3, 1991·The New England Journal of Medicine·N WeidnerJ Folkman
May 1, 1986·Microvascular Research·L E Gerlowski, R K Jain
Jan 1, 1987·Cancer Metastasis Reviews·R K Jain
Oct 1, 1986·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·S H KoenigG L Wolf
Sep 1, 1995·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·M Y SuO Nalcioglu
May 1, 1993·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·D M ShamesR C Brasch
Jan 1, 1997·Journal of Magnetic Resonance Imaging : JMRI·R BraschO Melnyk
Jan 1, 1997·Journal of Magnetic Resonance Imaging : JMRI·T P Roberts
Mar 21, 1998·American Journal of Obstetrics and Gynecology·A ObermairG Gitsch
Jun 24, 1998·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·B V OffersenJ Overgaard
Aug 21, 2001·European Radiology·P WunderbaldingerT Rand
Nov 10, 2001·European Radiology·G H MostbeckK Turetschek

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Citations

Oct 13, 2001·NMR in Biomedicine
Mar 27, 2007·Pharmaceutical Research·Renu M Stephen, Robert J Gillies
Dec 7, 2002·Magnetic Resonance Imaging·F FranconiS Akoka
Feb 3, 2005·Journal of the National Cancer Institute·Janet C MillerJames H Thrall
Feb 17, 2006·Investigative Radiology·Anda PredaCornelius F van Dijke
Oct 18, 2007·Radiology·Daniel J A MargolisSanjiv S Gambhir
Oct 1, 2004·The British Journal of Radiology·A R Padhani
Jul 30, 2014·IEEE Transactions on Medical Imaging·Ryan J HalterKeith D Paulsen
Apr 1, 2005·Proceedings of the IEEE·Barjor GimiZaver M Bhujwalla
Nov 12, 2013·Diagnostic and Interventional Imaging·C A Cuenod, D Balvay
Mar 9, 2004·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Xiaobing FanGregory S Karczmar
Sep 12, 2015·Korean Journal of Radiology : Official Journal of the Korean Radiological Society·Hee Sun ParkByung Ihn Choi
Aug 1, 2006·Journal of Magnetic Resonance Imaging : JMRI·Claudia WeidensteinerPeter R Allegrini
Sep 21, 2006·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Christine BaudeletBernard Gallez
Oct 31, 2007·Journal of Magnetic Resonance Imaging : JMRI·Mark M MoasserNola M Hylton
Sep 15, 2005·Journal of Magnetic Resonance Imaging : JMRI·Mary E SpilkerPaolo Vicini

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