PMID: 9422921Jan 10, 1998Paper

Assessment of a standard treatment protocol on visual outcome following presumed bacterial endophthalmitis

The British Journal of Ophthalmology
N OkhraviS Lightman

Abstract

The aim of this prospective study was, firstly, to judge the effect of early aggressive treatment with a standardised regimen of high dose broad spectrum intraocular and systemic antibiotics on visual outcome and, secondly, to assess the sensitivity of isolated organisms to the treatment regimen utilised. Thirty two consecutive patients presenting with presumed bacterial endophthalmitis were treated and completed follow up. In every case, intraocular sampling was undertaken and treatment with intraocular vancomycin, amikacin, and systemic ciprofloxacin was commenced immediately, followed by systemic steroids 1 day later. In 69% of patients vision improved with 47% achieving a final visual acuity of 6/36 or better and 31% achieving 6/12 or better. Of the intraocular samples taken from post-surgical and post-traumatic cases, 10/27 (37%) and 3/5 (60%) were culture positive, respectively. All the bacteria isolated were sensitive to at least one of the three antibiotics used. The study demonstrated that the combination of vancomycin, amikacin, and ciprofloxacin is adequate as a standard regimen for the treatment of most patients with suspected bacterial endophthalmitis. The prognosis for a good visual outcome, however, remains poor ...Continue Reading

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Citations

Aug 30, 2001·Survey of Ophthalmology·A Ramsay, S Lightman
Mar 8, 2003·Ophthalmology·Aires Lobo, Susan Lightman
Feb 29, 2000·Eye·D C MurrayM Hero
Nov 28, 2007·Retina·Emily J WellsCharles C Barr
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Oct 20, 2005·The British Journal of Ophthalmology·J I PrydalA Watts
Oct 12, 2012·Mediators of Inflammation·Mónica Asencio-DuranMario R Romano
Sep 26, 2013·Ocular Immunology and Inflammation·Shailaja S BhatPrachi Vikramsinh Parmar
Aug 3, 2011·Progress in Retinal and Eye Research·Marc D de SmetSue Lightman
Oct 1, 2003·Clinical & Experimental Ophthalmology·Brendan Vote
Feb 14, 2018·International Journal of Molecular Sciences·Seoh Wei TehSuresh Kumar Subbiah
Feb 28, 2014·Journal of Clinical Microbiology·Rajagopalaboopathi JayasudhaSolai Ramatchandirane Prabagaran
Jan 13, 2006·Clinical & Experimental Ophthalmology·Harkiran Manku, Peter McCluskey
Nov 13, 2002·Clinical & Experimental Ophthalmology·Mark J ElderUNKNOWN EPSWA. Endophthalmitis Population Study of Western Australia
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Dec 3, 2005·Ocular Immunology and Inflammation·Harvey S UyFilipinas Natividad
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Apr 25, 2020·Microbial Pathogenesis·KrishnanNair Geetha Deepthi, Solai Ramatchandirane Prabagaran
Feb 12, 1998·Journal of Clinical Microbiology·N OkhraviS Lightman

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