Assessment of activity of an adhesion molecule CD134 and CD137 in colorectal cancer patients

Polski przeglad chirurgiczny
D CepowiczBogusław Kędra

Abstract

Epidemiological studies prove that incidence of colorectal cancer is increasing. The first line therapy of colorectal cancer is surgical resection of the primary tumor and elimination of regional and remote metastases. THE AIM OF THE STUDY was to determine expression of adhesion molecules CD134 and CD137 in the peripheral blood in colorectal cancer patients, depending on clinical cancer stage, size and invasion of the tumor. The study enrolled 72 patients with primary colorectal adenocarcinoma. An average patient age was 64.55 years. Clinical tumor stage was assessed using two scales: Dukes: A and Astler-Coller scale. Expression of adhesion molecules was determined in the peripheral blood collected on the day of the procedure and 10 days after the procedure. An average activity of CD134 molecules (12.66%) was significantly higher than that of CD137 (6.26%) (p<0.001). Clinical tumor stage was assessed on Dukes scale and was unrelated to CD134 activity, while activity of CD137 was related to clinical cancer stage. CD137 activity is directly proportional to colorectal cancer stage. Surgical resection of the tumor results in increased CD134 and CD137 expression. Long term studies, enrolling larger groups of patients, including thei...Continue Reading

References

Oct 6, 1999·Current Opinion in Immunology·M S CraggM J Glennie
Feb 5, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·A D WeinbergJ Shields
Jul 19, 2000·Molecular Therapy : the Journal of the American Society of Gene Therapy·S H ChenS L Woo
Apr 30, 2002·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·N C TebbuttD Kerr
May 7, 2002·Molecular Therapy : the Journal of the American Society of Gene Therapy·Philipp Mayer-KuckukJoseph R Bertino
Oct 16, 2002·Molecular Therapy : the Journal of the American Society of Gene Therapy·Ping-Ying PanShu-Hsia Chen
Jun 6, 2003·Cytokine & Growth Factor Reviews·Michael Croft
Apr 1, 2004·International Journal of Cancer. Journal International Du Cancer·Iñigo TirapuIgnacio Melero
Apr 23, 2004·Trends in Immunology·Laura SanzLuis Alvarez-Vallina
Apr 6, 2006·Oncology Reports·Jan DimbergDick Wågsäter
Apr 27, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Nan ZhangAlan L Epstein
Aug 19, 2007·Medicinal Research Reviews·Simone Mocellin, Donato Nitti
Nov 6, 2007·Advanced Drug Delivery Reviews·Alberto BallestreroAlessio Nencioni
Nov 9, 2007·World Journal of Gastroenterology : WJG·Guillermo MazzoliniIgnacio Melero

❮ Previous
Next ❯

Citations

Nov 26, 2015·Journal of Immunology Research·Julie JacobsVanessa Deschoolmeester

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.