Assessment of adherence to antiretroviral therapy in perinatally HIV-infected children and youth using self-report measures and pill count.

Journal of Developmental and Behavioral Pediatrics : JDBP
John J FarleyPACTG P1042S Team

Abstract

Parent/caregiver or child/youth self-report and pill counts are commonly used methods for assessing adherence to antiretroviral therapy among children and youth with HIV. The purpose of this study was to compare these different methods with one another and with viral load. Randomly selected parent/caregiver and child/youth dyads were interviewed using several adherence self-report measures and an announced pill count was performed. Adherence assessment methods were compared with one another and their relative validity was assessed by comparison with the child's viral load close to the time of the interview or pill count, adjusting for primary caregiver, child age, and child disclosure of the diagnosis. There were 151 evaluable participants. Adherence rate by pill count was >or=90% in 52% of participants, was significantly associated with log(RNA) viral load (p = .032), and had significant agreement with viral load <400 copies/mL. However, pill count data were incomplete for 26% of participants. With similar proportions considered adherent, a variety of self-report adherence assessment methods also were associated with log(RNA) viral load including: "no dose missed within the past 1 month" (p = .054 child/youth interview, p = .0...Continue Reading

References

Aug 1, 1990·Journal of Pediatric Psychology·B J AndersonJ V Santiago
Jan 6, 2001·The Pediatric Infectious Disease Journal·C ReddingtonH W Hsu
Jan 17, 2002·The New England Journal of Medicine·S L GortmakerUNKNOWN Pediatric AIDS Clinical Trials Group Protocol 219 Team
Apr 3, 2002·Pediatrics·Russell B Van DykeUNKNOWN Pediatric AIDS Clinical Trials Group Adherence Subcommittee Pediatric AIDS Clinical Trials Group 377 Study Team
Jan 25, 2003·The Pediatric Infectious Disease Journal·Diana M GibbUNKNOWN Paediatric European Network for Treatment of AIDS Steering Committee
Jun 17, 2003·Journal of Pediatric Psychology·Curtis DolezalElaine J Abrams
Jan 5, 2005·Pediatrics·Deborah S StormUNKNOWN Pediatric AIDS Clinical Trials Group Protocol 219 Study Team
Jan 6, 2005·AIDS Patient Care and STDs·Lori WienerLauren V Wood
Mar 15, 2005·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Pythia T Nieuwkerk, Frans J Oort
Apr 19, 2005·AIDS Care·S Naar-KingC Arfken
Feb 3, 2006·Pediatrics·Grace M LeeUNKNOWN Pediatric AIDS Clinical Trials Group Protocol 219C Team
Mar 4, 2006·Journal of Pediatric Psychology·Stephanie L MarhefkaClaude Ann Mellins
Nov 30, 2006·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Karina M Berg, Julia H Arnsten

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Citations

Nov 26, 2009·Administration and Policy in Mental Health·Michelle R MunsonLisa Townsend
May 1, 2013·Journal of Pediatric Psychology·Sylvie Naar-KingUNKNOWN PACTG P1042s Team
Mar 1, 2012·Journal of Developmental and Behavioral Pediatrics : JDBP·Sharon L NicholsUNKNOWN PACTG P1042S Team
Dec 20, 2012·The Pediatric Infectious Disease Journal·Chloe A TeasdaleLouise Kuhn
Jun 6, 2014·AIDS Patient Care and STDs·Jintana IntasanUNKNOWN PREDICT Study Group
Oct 26, 2010·The Journal of Adolescent Health : Official Publication of the Society for Adolescent Medicine·Patricia A GarvieJ Christopher Young
Mar 7, 2015·The Brazilian Journal of Infectious Diseases : an Official Publication of the Brazilian Society of Infectious Diseases·Horacio A DuarteUNKNOWN NISDI PLACES Study Group
Apr 5, 2014·Child Neuropsychology : a Journal on Normal and Abnormal Development in Childhood and Adolescence·Renee Smith, Megan Wilkins
Aug 8, 2020·Health Expectations : an International Journal of Public Participation in Health Care and Health Policy·Hailay Abrha GesesewLillian Mwanri
Jun 2, 2021·The Journal of Adolescent Health : Official Publication of the Society for Adolescent Medicine·Lisa M IngerskiMegan L Wilkins
Sep 30, 2016·Pediatrics·Mary C Smith FawziTheresa S Betancourt

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