Assessment of adherence to atovaquone-proguanil prophylaxis in travelers

Journal of Travel Medicine
John C DePetrilloMiriam A Smith

Abstract

Malaria continues to be a serious, world-wide infection. Atovaquone-proguanil is one of the prophylactic agents recommended for travelers to endemic regions. However, little information is available regarding adherence with this medication. A large proportion of malaria cases reported from travelers is due to non-adherence to prescribed regimens. This study was undertaken to analyze adherence with atovaquone-proguanil prophylaxis and specific factors contributing to non-adherence. Men and non-pregnant women > or = 18 years of age were eligible for inclusion. Enrolled travelers received a prescription for atovaquone-proguanil prophylaxis and were contacted by telephone within 3 weeks of return to the United States. A questionnaire was prepared by the authors to determine if subjects were adherent with the medication. Additional data included demographics, duration of malarious travel, previous use of prophylactic agents, underlying medical conditions, concurrent medications, and reasons for non-adherence. Complete data were available for 104/124 (84%) participants: 49 (47%) men, 55 (53%) women. Average duration of malarious travel was 12 days, and 19 (18%) travelers reported previous travel to a malarious region. Ninety-two (89%...Continue Reading

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Citations

Aug 2, 2013·Malaria Journal·Klaske Vliegenthart-JongbloedPerry J J van Genderen
Apr 4, 2014·Scandinavian Journal of Infectious Diseases·Martin AngelinHelena Palmgren
Feb 6, 2013·Journal of Travel Medicine·Peter A Leggat
Jul 5, 2011·Journal of Travel Medicine·Larry GoodyerAlan Martin
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Apr 13, 2019·PloS One·Abdoulkader Ali AdouItalo Francesco Angelillo
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Sep 12, 2019·Journal of Travel Medicine·Viola Del PretePietro Ferrara
Nov 19, 2020·Patient Preference and Adherence·Chaturaka RodrigoSumadhya Deepika Fernando

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