PMID: 11312405Apr 20, 2001Paper

Assessment of airway neutrophils by sputum colour: correlation with airways inflammation

Thorax
R A StockleyE J Campbell

Abstract

Airway inflammation, with recruitment of neutrophils to the airway lumen, results in purulent secretions and a variety of potential adverse consequences for patients with chronic bronchitis and bronchiectasis. We hypothesised that gradations of sputum colour would correlate directly with the myeloperoxidase content of sputum and with various other indicators of the activity and consequences of bronchial diseases. To test this hypothesis, we quantified sputum colour by reference to a sensitive nine point colour chart and correlated this assessment with indices of a number of inflammatory mediators in sputum. The results indicate that standardised visual measurements of sputum colour correlated strongly with myeloperoxidase, interleukin 8, leucocyte elastase (both activity and total quantity), sputum volume, protein leak, and secretory leucocyte proteinase inhibitor (p<0.001 for all). In addition, there was a strong direct correlation between leucocyte elastase and both myeloperoxidase (p<0.003) and sputum volume (p<0.001), but a strong negative correlation with secretory leucocyte proteinase inhibitor (p<0.001). These results indicate that sputum colour graded visually relates to the activity of the underlying markers of bronchi...Continue Reading

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Citations

Mar 20, 2010·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Devipriya SubramaniyamSabina Janciauskiene
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