PMID: 9165994Apr 1, 1997Paper

Assessment of anti-endothelial cell antibodies in systemic sclerosis and Sjögren's syndrome

Annals of the Rheumatic Diseases
M HebbarA Janin

Abstract

Anti-endothelial cell antibodies (AECA) have been detected in 19 to 30% of patients with systemic sclerosis (SSc). The objective of this study was first to assess the role of a secondary Sjögren's syndrome (SS) in the occurrence of AECA in SSc. Secondly, we researched AECA in patients with primary SS, and investigated whether AECA were associated with vascular manifestations (Raynaud's phenomenon and vasculitis). IgG-AECA were tested by an ELISA method in serum samples from 50 patients with SSc (16 of them had also a secondary SS), 50 patients with primary SS, and 50 healthy controls. AECA levels were significantly higher in patients with SSc or primary SS than in healthy controls (p < 0.01 and p < 0.01, respectively). In patients with SSc, AECA values were significantly higher in patients with secondary SS (p < 10(-5)). In patients with primary SS, AECA levels were significantly higher in patients with Raynaud's phenomenon (p < 0.01), but not in patients with vasculitis. In patients with SSc, AECA are associated with a secondary SS. In patients with primary SS, AECA are associated with Raynaud's phenomenon, but not with vasculitis.

References

Jun 1, 1977·International Journal of Dermatology·R Fleischmajer
Apr 1, 1987·Annals of the Rheumatic Diseases·J CollA Balcells
Mar 1, 1984·The Journal of Clinical Investigation·D B CinesR J DeHoratius

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Citations

Feb 18, 2011·Rheumatology International·Navin MishraK C Shiva Raj
Mar 12, 2005·Archives of Physical Medicine and Rehabilitation·Vivian C ShihAndrew N Vo
May 5, 2009·Nature Reviews. Rheumatology·Ji Hyeon JuHo-Youn Kim
Mar 30, 2006·Annals of the Rheumatic Diseases·C BeliznaJ W Cohen Tervaert
Jul 15, 2005·Annals of the New York Academy of Sciences·Nabil SaklyMassoud Mirshahi
Aug 20, 2019·Clinical Rheumatology·John D PaulingJanet E Pope
Apr 17, 2015·Current Rheumatology Reports·Angela Kill, Gabriela Riemekasten
Jun 28, 2002·Pathologie-biologie·Nicole Fabien, Hugues Rousset
Jul 5, 2003·Rheumatic Diseases Clinics of North America·Janet E Pope

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