Assessment of antihypertensive drug use in primary care in Ravenna, Italy, based on data collected in the PANDORA project

Clinical Therapeutics
Alessandra SturaniPANDORA Study Group

Abstract

In the clinical-practice setting, only a small percentage of patients treated with antihypertensive drugs become normotensive. Furthermore, the diversity of drug classes used makes comparison of treatments difficult. The goal of this study was to characterize the types and efficacy of antihypertensive treatments used in primary care in the area of Ravenna, Italy. The study was conducted in the context of the PANDORA Project, an open-ended global outcome study. Data were gathered from general practitioners (GPs) and were stored by the GPs or through links with national health service databases. The population of interest was patients with essential hypertension taking antihypertensive medication, each of whom was observed for 365 days. Blood pressure was measured in the morning or afternoon using an automated device, in accordance with normal clinical practice. At each office visit, the GP reviewed and made any necessary adjustments to the patient's antihypertensive treatment. Antihypertensive drug use was assessed by calculating the mean daily dose (MDD) of the prescribed drug and the duration of treatment (DT). A DT > or = 273 days constituted continuous therapy, and a DT <273 days constituted discontinuous therapy. Adverse ev...Continue Reading

References

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Citations

Feb 7, 2007·European Journal of Clinical Pharmacology·Adnan AbaciCetin Erol
Mar 4, 2011·International Journal of Clinical Pharmacy·Hong Cheng
Nov 13, 2002·Pharmacoepidemiology and Drug Safety
Feb 20, 2004·Journal of Human Hypertension·E Degli EspostiS Buda
Jul 30, 2003·The Medical Journal of Australia·Esther M BrigantiUNKNOWN Australian Diabetes, Obesity and Lifestyle Study (AusDiab)

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