Assessment of Antimicrobial and Antioxidant Activities of Nepeta trachonitica: Analysis of Its Phenolic Compounds Using HPLC-MS/MS

Scientia pharmaceutica
Ekrem KöksalErcan Bursal

Abstract

Continuing our work on the sources of natural bioactive compounds, we evaluated the antimicrobial and antioxidant activities of Nepeta trachonitica as well as its major phenolic content using the high-performance liquid chromatography-mass spectrometry/mass spectrometry (HPLC-MS/MS) technique. For antioxidant activity, ferric reducing antioxidant power (FRAP) and cupric ion reducing antioxidant capacity (CUPRAC) methods were performed to measure the reducing power and 1,1-diphenyl-2-picrylhydrazyl (DPPH) assay was employed to evaluate the radical scavenging activity of the sample. For antimicrobial activity, three Gram-positive and four Gram-negative microbial species as well as three fungi species were tested. N. trachonitica appeared to have reasonable antioxidant activity and decent antimicrobial activity as indicated by the inhibition of the organisms' growth. The most susceptible species were Bacillus subtilis ATCC 6633 and Escherichia coli ATCC 11229 among the organisms tested. Ethanol extract of the plant has the highest effect on Saccharomyces cerevisiae but no effect on Yarrowia lipolytica. The HPLC-MS/MS analysis showed that at least 11 major phenolic compounds of N. trachonitica exist, the major ones being rosmarinic...Continue Reading

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Citations

Aug 23, 2017·Artificial Cells, Nanomedicine, and Biotechnology·Ericka Rodríguez-LeónJuan Manuel Martínez-Soto
Jan 1, 2019·Journal of Biochemical and Molecular Toxicology·Uğur TutarHayreddin Gezegen
Sep 17, 2020·Journal of Biomolecular Structure & Dynamics·Gurusamy Sankararaj SenthilkumarRadhakrishnan Nandini Asha
Dec 12, 2020·Journal of Ethnopharmacology·Ajay SharmaDamanjit Singh Cannoo
Sep 20, 2017·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Adel M A AssiriMohamed Fawzy Ramadan
Dec 15, 2020·Scientific Reports·R Venkatesh KumarRajesh Kumar
Jun 3, 2020·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Zahra Aramesh-BoroujeniMeissam Noroozifar

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