Assessment of aortic stiffness in patients with ankylosing spondylitis using cardiovascular magnetic resonance

Clinical Rheumatology
P Stefan BiesbroekRobin Nijveldt

Abstract

To evaluate aortic stiffness in patients with ankylosing spondylitis (AS) using cardiovascular magnetic resonance (CMR) and to assess its association with AS characteristics and left ventricular (LV) remodeling. In this prospective study, 14 consecutive AS patients were each matched to two controls without cardiovascular symptoms or known cardiovascular disease who underwent CMR imaging for the assessment of aortic arch pulse wave velocity (PWV) at 1.5 Tesla. To enhance comparability of the samples, matching was done with replacement resulting in 20 unique controls. Only AS patients with abnormal findings on screening echocardiography were included in this exploratory study. Cine CMR was used to assess LV geometry and systolic function, and late gadolinium enhancement was performed to determine the presence of myocardial hyperenhancement (i.e., fibrosis). Aortic arch PWV was significantly higher in the AS group compared with the control group (median 9.7 m/s, interquartile range [IQR] 7.1 to 11.8 vs. 6.1 m/s, IQR 4.6 to 7.6 m/s; p < 0.001). PWV was positively associated with functional disability as measured by BASFI (R: 0.62; p = 0.018). Three patients (21%) with a non-ischemic pattern of hyperenhancement showed increased PWV ...Continue Reading

References

Sep 27, 2006·European Heart Journal·Stephane LaurentUNKNOWN European Network for Non-invasive Investigation of Large Arteries
May 13, 2008·Journal of Clinical Epidemiology·Anne M EuserSaskia le Cessie
Dec 9, 2008·Annals of the Rheumatic Diseases·D van der HeijdeUNKNOWN Assessment of SpondyloArthritis international Society (ASAS)
Aug 28, 2009·Journal of Magnetic Resonance Imaging : JMRI·Heynric B GrotenhuisAlbert de Roos
Oct 8, 2009·Circulation. Heart Failure·Tatiana KuznetsovaJan A Staessen
Dec 4, 2009·The Journal of Rheumatology·Mike J L PetersMichael T Nurmohamed
Mar 27, 2010·Journal of the American College of Cardiology·Charalambos VlachopoulosChristodoulos Stefanadis
Sep 28, 2010·Statistical Science : a Review Journal of the Institute of Mathematical Statistics·Elizabeth A Stuart
Jan 18, 2011·The Journal of Rheumatology·Nóra BodnárSándor Szántó
Mar 11, 2011·Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance·Marijn P RolfRob M Heethaar
Feb 22, 2012·Nature Reviews. Rheumatology·György KerekesZoltán Szekanecz
Mar 7, 2014·Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance·Ntobeko A B NtusiTheodoros D Karamitsos
Mar 25, 2014·Seminars in Arthritis and Rheumatism·Sjoerd C HeslingaMichael T Nurmohamed
Jun 3, 2014·Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance·Christopher D MaroulesKevin S King
Dec 3, 2014·Atherosclerosis·Snigdha JainJulio A Chirinos
Apr 22, 2015·JACC. Cardiovascular Imaging·Ntobeko A B NtusiTheodoros D Karamitsos
Sep 12, 2015·European Heart Journal Cardiovascular Imaging·Chikara NodaJoao A C Lima
Feb 8, 2016·The International Journal of Cardiovascular Imaging·Galia KarpMahmoud Abu-Shakra

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiac Remodeling

Cardiac remodeling in response to a myocardial infarction is characterized by progressive ventricular dilatation, cardiac hypertrophy, fibrosis, and deterioration of cardiac performance. Discover the latest research on Cardiac Remodeling here.

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.