PMID: 16521447Mar 9, 2006Paper

Assessment of apoptosis measured with TUNEL in laryngeal cancer

Otolaryngologia polska. The Polish otolaryngology
W PietruszewskaM Gryczyński

Abstract

Programmed cell death is a combined intracellular process. For the activation of apoptosis as proapoptotic genes and antiapoptotic ones are needed as well. There are several methods of apoptosis assessment but in laryngeal cancer prognostic value of apoptotic index is still unclear. 44 patients with laryngeal cancer who received surgical treatment in ENT Department of Medical University of Lodz were analysed. Apoptotic index (AI) was studied by TUNEL assay (TdT-mediated dUTP nick and labeling). There were assessed correlation between AI and primary tumor size and nodal status based on TNM system; local and nodal recurrences; and survival rate after surgical treatment. We observed significant correlation between AI and degree of neoplastic cell polymorphism (p=0,043) and tumor size (T feature) (p=0,01). IA was also significantly correlated with epiglottic site of tumor (p=0,036). There were no correlation between IA and N or M features, local and nodal recurrences or survival rate. Based on these findings we conclude that apoptosis index can be a valuable in prognostic assessment of patients with laryngeal cancer.

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

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