Assessment of Apoptosis Pathway in Peripheral Blood of Autistic Patients.

Journal of Molecular Neuroscience : MN
Mohammad Mahdi EftekharianSoudeh Ghafouri-Fard

Abstract

Autism spectrum disorder (ASD) includes a number of severe neurodevelopmental disorders known by defects in social interaction, impaired verbal and non-verbal interactions, and stereotypic activities and limited interests. Dysregulation of apoptotic pathways have been demonstrated in brain tissues of affected individuals. In the present study, we evaluated expression levels of apoptosis-related genes and miRNAs in peripheral blood of ASD patients compared with healthy subjects. Transcript levels of BCL2, CASP8, and hsa-29c-3p were significantly lower in total ASD patients compared with total normal children (P values = 0.003, 0.002, and 0.01 respectively). When sex of study participants was considered in the analysis, the difference in transcript levels of these genes was significant only in male subjects. Peripheral expression of BCL2 and hsa-29c-3p had 100% sensitivity 92% specificity in ASD diagnosis. The diagnostic power of combination of transcript levels of these genes was estimated to be 78% based on the calculated AUC value. The present study provides evidences for dysregulation of apoptotic pathways in peripheral blood of ASD patients and suggests certain apoptosis-related genes as biomarkers in this regard.

References

Jun 1, 1985·Neurology·M Bauman, T L Kemper
Aug 1, 1995·Archives of Neurology·B EgaasO Saitoh
Jan 5, 2002·Mental Retardation and Developmental Disabilities Research Reviews·K A Roth, C D'Sa
Jan 30, 2002·Journal of Autism and Developmental Disorders·S H FatemiG R Realmuto
Jan 2, 2004·The American Journal of Psychiatry·L Fredrik JarskogJohn H Gilmore
Feb 18, 2004·Cellular and Molecular Neurobiology·Mohsen Araghi-Niknam, S Hossein Fatemi
Jul 16, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Cynthia Mills SchumannDavid G Amaral
Mar 8, 2005·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Margaret L Bauman, Thomas L Kemper
May 24, 2005·Progress in Neuro-psychopharmacology & Biological Psychiatry·L Fredrik JarskogJeffrey A Lieberman
Mar 10, 2006·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Patrick F SullivanCharles M Perou
Aug 31, 2006·Journal of Neuroscience Research·Tsutomu SasakiMasatsugu Hori
Feb 9, 2008·Trends in Neurosciences·David G AmaralChristine Wu Nordahl
Oct 23, 2008·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Young-Pil YunYoung Lim
Jul 22, 2010·Journal of Neuroscience Research·Ashfaq M SheikhXiaohong Li
May 14, 2011·Brain Research·Yuanyuan ZongChuan Qin
Oct 5, 2011·Journal of Autism and Developmental Disorders·Dario SiniscalcoNicola Antonucci
Nov 8, 2011·Journal of Autism and Developmental Disorders·Amanda Mossman SteinerKatarzyna Chawarska
Jan 31, 2012·Pediatric Clinics of North America·Ahsan Nazeer, Mohammad Ghaziuddin
Aug 31, 2013·Journal of Autism and Developmental Disorders·Patricia J M Van Wijngaarden-CremersRutger Jan Van der Gaag
Apr 2, 2014·International Journal of Medical Sciences·Hongyan ZuoHongmei Zhou
May 7, 2014·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Hongen WeiXiaohong Li
Oct 1, 2014·Journal of Toxicology and Environmental Health. Part a·Manivannan JothiramajayamAnita Mukherjee
Feb 20, 2016·Cell Death & Disease·R VenkatadriN Azad
Dec 31, 2016·Journal of Alzheimer's Disease : JAD·Yuji KamikuboTakashi Sakurai
Dec 19, 2017·Folia Phoniatrica Et Logopaedica : Official Organ of the International Association of Logopedics and Phoniatrics (IALP)·Kakia Petinou, Despo Minaidou
Jan 14, 2018·Scientific Reports·Di WuElizabeth B Torres
May 16, 2018·Autism Research : Official Journal of the International Society for Autism Research·Daoyin DongPeixin Yang
Jul 7, 2018·Environmental Pollution·Almudena Espín-PérezTheo M C M de Kok

❮ Previous
Next ❯

Methods Mentioned

BETA
PCR

Related Concepts

Related Feeds

Autism

Autism spectrum disorder is associated with challenges with social skills, repetitive behaviors, and often accompanied by sensory sensitivities and medical issues. Here is the latest research on autism.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis