Apr 16, 2013

Assessment of autonomic dysfunction in patients with type 2 diabetes using reactive hyperemia

Journal of Theoretical Biology
Hsien-Tsai WuMen-Tzung Lo

Abstract

It is known that aging and type 2 diabetes mellitus contribute to atherosclerosis and autonomic dysfunction. By using the air pressure sensing system (APSS), peak-peak intervals (PPIs) of wrist arterial waveforms from baseline and reactive hyperemia (RH) were obtained. Through frequency domain analysis of heart rate variability (HRV) and nonlinear Poincaré method, the HRV of healthy young individuals (Group 1, n=25), healthy upper middle-aged individuals (Group 2, n=22), and patients with type 2 diabetes (Group 3, n=28) were assessed. By using the standard deviation (SD) of the instantaneous PPI variability (SD1)/the SD of the long PPI variability (SD2) ratio (SSR), PPIs of the same individuals before and after RH induction were compared. Reduced SSR₁₋₁₀ was noted only in patients with diabetes. Moreover, a significient correlation between SSR₁₋₁₀ and endothelial function was observed in all subjects (r=0.290, p=0.033) after RH. However, no correlation with low-frequency to high-frequency power ratio (LHR) was noted before and after RH. In conclusion, according to our results, campared to the baseline, there were more significant changes of SSR₁₋₁₀ after RH in patients with diabetes; and, a significient correlation between SSR₁...Continue Reading

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  • Citations3

Citations

Mentioned in this Paper

Glycated Hemoglobin TEST
Autonomic Nervous System Disorders
Rh-Null, Regulator Type
Ischemia
Diabetes Mellitus, Non-Insulin-Dependent
Peeling Skin Syndrome, Acral Type
Fluctuation
Myoclonic Epilepsies, Progressive
Serotonin Reuptake Inhibitor [EPC]
Reactive Hyperemia

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