Assessment of axonal fiber tract architecture in excised rat spinal cord by localized NMR q-space imaging: simulations and experimental studies

Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine
Chih-Liang ChinD B Hackney

Abstract

NMR q-space imaging is a method designed to obtain information from porous materials where diffusion-diffraction phenomena were observed from which pore size was derived. Recently, the technique has been applied to the study of biological structures as well. Although diffusive diffraction has so far not been observed in multicellular systems, displacement profiles have been used with some success as a means to estimate structure size. However, there have been no quantitative correlations of the retrieved structure sizes with histology. Clearly, the complexity of tissue architecture poses significant challenges to the interpretation of q-space data. In this work, simulations were first performed on a two-compartment model to demonstrate the effects of interference of the diffraction patterns arising from intra and extra-axonal compartments and finite boundary permeability on q-space data. Second, q-space echo attenuation was simulated on the basis of histologic images of various rat spinal cord fiber tracts and the information obtained from the displacement profiles were compared with structural parameters computed from the histologic images. The results show that calculated mean displacements and kurtosis parallel mean axon siz...Continue Reading

References

Jun 1, 1990·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·D G Cory, A N Garroway
Jun 1, 1993·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·W A StewartD W Paty
Jan 1, 1997·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·G J StaniszR M Henkelman
May 1, 1997·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·P W KuchelP Stilbs
Dec 24, 1997·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·M D KingA Connelly
Nov 5, 1999·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·S PeledF A Jolesz
May 29, 2000·The Journal of Spinal Cord Medicine·B A Kakulas
Nov 7, 2000·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Y AssafY Cohen
Jun 1, 2001·Journal of Magnetic Resonance·S C LeeC Cheong
Jul 16, 2002·Magnetic Resonance Imaging·Revital Nossin-ManorYoram Cohen
Nov 7, 2002·Journal of Magnetic Resonance·L CiobanuC H Pennington
Jul 24, 2003·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Scott N HwangDavid B Hackney

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Citations

Mar 3, 2007·Magnetic Resonance in Medical Sciences : MRMS : an Official Journal of Japan Society of Magnetic Resonance in Medicine·Eizou UmezawaEiji Tanaka
May 17, 2006·Proceedings of the National Academy of Sciences of the United States of America·Denis Le BihanHidenao Fukuyama
Nov 29, 2007·IEEE Transactions on Medical Imaging·Jimmy LättSara Brockstedt
Nov 17, 2009·Experimental Neurology·Karen Ollivier-LanvinMichel A Lemay
Jun 23, 2015·NeuroImage·Tanguy DuvalJulien Cohen-Adad
Aug 13, 2008·NeuroImage·Gregor KasprianDaniela Prayer
Jul 31, 2007·Microscopy Research and Technique·Luiza LarsenHubertus Axer
Feb 11, 2009·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Junzhong XuJohn C Gore
Sep 29, 2009·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Kevin D HarkinsTheodore P Trouard
Apr 8, 2010·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Adrienne N DulaMark D Does
May 1, 2010·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Jonathan A D FarrellPeter C M van Zijl
Mar 22, 2007·Physics in Medicine and Biology·Denis Le Bihan
Jun 30, 2011·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Kevin D HarkinsMark D Does
Jun 5, 2014·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Marco PalomboSilvia Capuani
Jun 9, 2016·Physics in Medicine and Biology·K D Harkins, M D Does
Jan 7, 2018·Magnetic Resonance Imaging·Vaibhav MohantyJens H Jensen
Jul 22, 2020·Journal of Neuroscience Methods·Ileana O JelescuKurt G Schilling

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