Assessment of Background Parenchymal Enhancement and Lesion Kinetics in Breast MRI of BRCA 1/2 Mutation Carriers Compared to Matched Controls Using Quantitative Kinetic Analysis

Academic Radiology
Alana A LewinLinda Moy

Abstract

To investigate whether quantitative kinetic analysis of lesions and background parenchyma in breast magnetic resonance imaging can elucidate differences between BRCA carriers and sporadic controls with high risk for breast cancer. Fifty-nine BRCA and 59 control cases (49 benign, 10 malignant) were examined in this study. Principal component analysis was applied for quantitative analysis of dynamic signal in background parenchyma (B) and lesion (L) in terms of initial enhancement ratio (IER) and delayed enhancement ratio (DER). Control B-IER, B-DER, L-IER, and L-DER were higher than BRCA cases in all women and in women with benign lesions; statistically significant differences in B-IER and B-DER (all women: P = 0.02 and P = 0.02, respectively; benign only: P = 0.005 and P = 0.005, respectively). In the control cohort, B-IER and B-DER were higher in the premenopausal women than in the postmenopausal women (P = 0.013 and 0.003, respectively), but not in the BRCA cohort; this led to significant differences in B-IER and B-DER between the control and the BRCA groups in the premenopausal women (P = 0.01 and 0.01, respectively) but not in the postmenopausal women. Results suggest possible differences in the vascular properties of backg...Continue Reading

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Citations

Jul 28, 2016·Breast Cancer Research : BCR·Shandong WuJules H Sumkin
Apr 21, 2019·Journal of Magnetic Resonance Imaging : JMRI·Geraldine J LiaoHabib Rahbar
Oct 22, 2016·Journal of Magnetic Resonance Imaging : JMRI·Sungheon Gene KimLinda Moy
Aug 25, 2018·Breast Cancer Research and Treatment·Janice S SungMalcolm C Pike
Mar 28, 2021·Gynécologie, Obstétrique, Fertilité & Sénologie·E de KermadecN Chabbert-Buffet

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