Assessment of bevacizumab conjugated to Cy5.5 for detection of head and neck cancer xenografts

Technology in Cancer Research & Treatment
K P WithrowEben L Rosenthal

Abstract

Optical fluorescent technology has the potential to deliver real time imaging of cancer into the operating room and the clinic. To determine the efficacy of fluorescently labeled anti-vascular endothelial growth factor (VEGF) antibody to be used as a cancer specific optical contrast agent to guide surgical resections, we evaluated the sensitivity and specificity of this agent to detect microscopic residual disease in a preclinical model of head and neck squamous cell carcinoma (HNSCC). Using a flank murine model, mice were xenografted with SCC-1 tumor cells and injected with anti-VEGF antibody (bevacizumab) conjugated to an optically active fluorophore (Cy5.5). Tumors underwent sub-total resections and were assessed for the presence of residual disease by fluorescent stereomicroscopy. Expected positive and negative biopsies were taken according to the presence or absence of fluorescence, respectively. Histology was used to confirm the presence or absence of disease. Biopsies taken from areas of fluorescence within the wound bed (n=18) were found to be histologically malignant in all but one biopsy. Samples taken from a non-fluorescing tumor bed (n=15) were found to be histologically benign in 11 of 15. These findings correlated...Continue Reading

References

Oct 1, 1991·Journal of Cranio-maxillo-facial Surgery : Official Publication of the European Association for Cranio-Maxillo-Facial Surgery·L A RavaszI van der Tweel
Aug 18, 2000·Investigative Radiology·S AchilefuR Rajagopalan
Aug 14, 2002·Seminars in Radiation Oncology·James A BonnerKevin P Raisch
Nov 8, 2002·Seminars in Oncology·David C Spaulding, Betsy O Spaulding
Nov 26, 2002·Clinical Colorectal Cancer·B D Gambill
Jan 31, 2004·International Journal of Radiation Oncology, Biology, Physics·Deborah CitrinKevin Camphausen
May 4, 2004·The Lancet Oncology·Marion Harris
Jan 20, 2005·Bioconjugate Chemistry·Yunpeng YeSamuel Achilefu
May 3, 2005·Journal of Cancer Research and Clinical Oncology·Wolfgang J KöstlerChristoph C Zielinski
May 13, 2005·Chest·Cherie P ParungoJohn V Frangioni
Jul 27, 2005·Journal of Cancer Research and Clinical Oncology·Panayiotis A KyzasNiki J Agnantis
Nov 23, 2005·Oncology·Napoleone Ferrara
Nov 29, 2005·International Journal of Experimental Pathology·Giovana R ThomasJacinto Regalado
Feb 18, 2006·Annals of Surgical Oncology·Edward G SolteszJohn V Frangioni
Mar 2, 2006·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·S C Lim
Jul 20, 2006·International Journal of Clinical Oncology·Eriko TokunagaYoshihiko Maehara
Jul 27, 2006·Neoplasia : an International Journal for Oncology Research·Yukihiro HamaHisataka Kobayashi

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Citations

Jul 10, 2010·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Stijn KeereweerClemens W G M Löwik
Aug 1, 2014·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Kurt R ZinnEben L Rosenthal
May 30, 2013·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Kristine E DayEben L Rosenthal
Mar 19, 2013·Journal of Healthcare Engineering·Supang Khondee, Thomas D Wang
Dec 15, 2015·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Michelle S BradburySnehal Patel
Oct 12, 2011·Head & Neck·Stijn KeereweerClemens W G M Löwik
Apr 26, 2013·The Laryngoscope·Kristine E DayEben L Rosenthal
Aug 15, 2014·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Ihab AtallahAmandine Hurbin
May 22, 2016·Oral Oncology·Hassan Iqbal, Quintin Pan
Mar 27, 2010·Rheumatology·Luke L GompelsEwa M Paleolog
May 17, 2018·Expert Review of Anticancer Therapy·Thinzar M LwinMichael Bouvet
Nov 10, 2012·Integrative Biology : Quantitative Biosciences From Nano to Macro·Michelle S BradburySnehal Patel
Jul 31, 2008·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Sharmeela KaushalMichael Bouvet
Jan 20, 2015·Annals of Surgery·Eben L RosenthalKurt R Zinn
Feb 27, 2021·Journal of Controlled Release : Official Journal of the Controlled Release Society·Mingzhu LiangHong Shan
Apr 5, 2014·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Susanne LütjeOtto C Boerman

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