Assessment of bone mineral density of the femoral head in dogs with early osteoarthritis

American Journal of Veterinary Research
Heather J ChalmersRory J Todhunter

Abstract

To compare the bone mineral density (BMD) of the proximal portion of the femur in dogs with and without early osteoarthritis secondary to hip dysplasia. 24 dogs (3 Greyhounds, 6 Labrador-Greyhound crossbreeds, and 15 Labrador Retrievers). Computed tomography (CT) of the pelvis, including a bone-density phantom, was performed for each dog. Centrally located transverse CT slices and a computer workstation were used to identify 16 regions of interest (ROIs) in the proximal portion of the femur. For each ROI, the mean Hounsfield unit value was recorded; by use of the bone-density phantom and linear regression analysis, those values were converted to equivalent BMD (eBMD). Mean eBMD values for the subchondral and nonsubchondral ROIs in dogs with and without osteoarthritis (determined at necropsy) were compared. A mixed-model ANOVA and post hoc linear contrasts were used to evaluate the effects of osteoarthritis, breed, and sex on the BMD value. At necropsy, osteoarthritis was detected in 14 hip joints in 9 dogs; all lesions included early cartilage fibrillation. After adjusting for breed and sex, eBMD in subchondral ROIs 8 and 12 (adjacent to the fovea) were 8% and 6% higher, respectively, in osteoarthritis-affected dogs, compared w...Continue Reading

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Citations

Aug 3, 2007·American Journal of Veterinary Research·Benjamin D YoungAlicia L Bertone
Sep 2, 2008·Osteoarthritis and Cartilage·M BouchguaS Laverty
Apr 14, 2016·The Veterinary Clinics of North America. Small Animal Practice·Elizabeth A Ballegeer
May 31, 2016·Veterinary Radiology & Ultrasound : the Official Journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association·Julie De LasalleSheila Laverty
Sep 24, 2008·Journal of Dental Research·T H El-BialyT J Royston
Apr 8, 2017·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Karin LucasPatrick Wefstaedt

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