Assessment of brain AT1-receptor on the nocturnal basal and angiotensin-induced thirst and sodium appetite in ovariectomised rats

Journal of the Renin-angiotensin-aldosterone System : JRAAS
André S MecawiLuís C Reis

Abstract

Considering the controversial data regarding the role of the brain renin-angiotensin system (RAS) on the thirst and sodium appetite in ovariectomised rats, we aimed to evaluate the role of the brain angiotensin II (Ang II) AT1-receptor on the nocturnal fluids intake. Groups of Wistar female rats were ovariectomised and chronically given oestrogen or vehicle to evaluate its influence on effects induced by i.c.v. injection of losartan, Ang I and Ang II. The i.c.v. losartan decreased basal water intake in the ovariectomised group. Ang II but not Ang I-induced nocturnal dipsogenic and natriorexigenic responses in ovariectomised rats. In oestrogen-treated rats, both peptides increased fluids intake. Previously, i.c.v. losartan abolished these effects in all groups. Oestrogen replacement decreased the nocturnal fluids intake, attenuated the losartan and Ang II effects, and highlighted the Ang I response. The present study has shown for the first time the involvement of AT1-receptor in regulating nocturnal basal water and salt intake in ovariectomised rats. In addition, our data have revealed an unexpected increased brain Ang I-mediated fluid intake in oestrogen-treated ovariectomised compared to ovariectomised rats, which was blocked...Continue Reading

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Citations

Aug 14, 2009·Clinical and Experimental Pharmacology & Physiology·A S MecawiL C Reis
Feb 14, 2009·Clinical and Experimental Pharmacology & Physiology·I G AraujoE L Olivares
Sep 26, 2012·Journal of Neuroendocrinology·A S MecawiJ Antunes-Rodrigues
Jan 11, 2016·Clinical and Experimental Pharmacology & Physiology·Natalia Soares Carvalho de SouzaEmerson Lopes Olivares
Dec 22, 2014·Neuroscience and Biobehavioral Reviews·Andre S MecawiJuan Arguelles
Apr 13, 2013·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·J Antunes-RodriguesL L K Elias
Feb 26, 2019·Journal of Neuroendocrinology·Cintia Yamila PorcariAndré Souza Mecawi
Sep 26, 2019·Experimental Physiology·V C Lopes-MenezesL C Reis
Jun 3, 2011·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Andre S MecawiJose Antunes-Rodrigues

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