Assessment of Breast Cancer Risk Factors Reveals Subtype Heterogeneity

Cancer Research
Johanna HolmKamila Czene

Abstract

Subtype heterogeneity for breast cancer risk factors has been suspected, potentially reflecting etiologic differences and implicating risk prediction. However, reports are conflicting regarding the presence of heterogeneity for many exposures. To examine subtype heterogeneity across known breast cancer risk factors, we conducted a case-control analysis of 2,632 breast cancers and 15,945 controls in Sweden. Molecular subtype was predicted from pathology record-derived IHC markers by a classifier trained on PAM50 subtyping. Multinomial logistic regression estimated separate ORs for each subtype by the exposures parity, age at first birth, breastfeeding, menarche, hormone replacement therapy use, somatotype at age 18, benign breast disease, mammographic density, polygenic risk score, family history of breast cancer, and BRCA mutations. We found clear subtype heterogeneity for genetic factors and breastfeeding. Polygenic risk score was associated with all subtypes except for the basal-like (Pheterogeneity < 0.0001). "Never breastfeeding" was associated with increased risk of basal-like subtype [OR 4.17; 95% confidence interval (CI) 1.89-9.21] compared with both nulliparity (reference) and breastfeeding. Breastfeeding was not associ...Continue Reading

References

Aug 30, 2000·Nature·C M PerouD Botstein
Jun 28, 2003·Proceedings of the National Academy of Sciences of the United States of America·Therese SorlieDavid Botstein
Jan 20, 2004·Journal of Medical Genetics·W D Foulkes
Jul 22, 2004·Journal of the National Cancer Institute·H JernströmS A Narod
Jun 22, 2005·Proceedings of the National Academy of Sciences of the United States of America·Saori FurutaWen-Hwa Lee
Jul 1, 2005·Breast Cancer Research : BCR·Jose RussoIrma H Russo
Nov 2, 2005·Breast Cancer Research and Treatment·Jacek GronwaldJan Lubinski
Jun 21, 2007·Breast Cancer Research and Treatment·Robert C MillikanCharles M Perou
Jan 31, 2008·Proceedings of the National Academy of Sciences of the United States of America·Suling LiuMax S Wicha
Sep 4, 2008·Acta Oncologica·Lotti BarlowMats Talbäck
Apr 4, 2009·Cancer Causes & Control : CCC·Katrina F TriversJ William Eley
May 26, 2009·Breast Cancer Research : BCR·Marilyn L KwanBette J Caan
Jun 9, 2009·European Journal of Epidemiology·Jonas F LudvigssonAnders Ekbom
Sep 24, 2010·Molecular Endocrinology·Daniel J Toft, Vincent L Cryns
Feb 22, 2011·Journal of Mammary Gland Biology and Neoplasia·Gemma Molyneux, Matthew J Smalley
Jul 14, 2012·PloS One·Carmen M RedondoJ Esteban Castelao
Aug 1, 2012·Breast Cancer Research : BCR·Jingmei LiKeith Humphreys
Oct 4, 2012·Annals of Oncology : Official Journal of the European Society for Medical Oncology·P Boyle
Mar 29, 2013·Nature Genetics·Kyriaki MichailidouDouglas F Easton
Aug 7, 2013·Annals of Oncology : Official Journal of the European Society for Medical Oncology·A GoldhirschUNKNOWN Panel members
Oct 15, 2013·Statistics in Medicine·Peter C Austin
Nov 2, 2013·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Katie M O'BrienRobert C Millikan
Sep 2, 2014·Journal of Internal Medicine·L EmilssonJ F Ludvigsson
Sep 17, 2014·Journal of the National Cancer Institute·Julie R PalmerChristine B Ambrosone
Dec 10, 2014·Annals of Oncology : Official Journal of the European Society for Medical Oncology·J LiK Czene
Jan 16, 2015·Comprehensive Physiology·William R Crowley
Apr 10, 2015·Journal of the National Cancer Institute·Nasim MavaddatMontserrat Garcia-Closas
Jun 15, 2015·Biochimica Et Biophysica Acta·Mollie E BarnardRulla M Tamimi
May 12, 2016·Breast Cancer Research : BCR·Mei WangMattias Rantalainen
Feb 10, 2017·International Journal of Epidemiology·Marike GabrielsonPer Hall

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Citations

Apr 1, 2018·International Journal of Cancer. Journal International Du Cancer·Louise ErikssonKamila Czene
Feb 2, 2018·Breast Cancer : the Journal of the Japanese Breast Cancer Society·Yiran WangYajie Wang
Sep 4, 2018·International Journal of Cancer. Journal International Du Cancer·Jingmei LiKamila Czene
Feb 11, 2020·Breast Cancer : the Journal of the Japanese Breast Cancer Society·Junxian LiKexin Chen
Dec 5, 2019·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Wei HeKamila Czene
Feb 19, 2020·International Journal of Cancer. Journal International Du Cancer·Jonine D FigueroaUNKNOWN Ghana Breast Health Study Team
Aug 29, 2020·International Journal of Cancer. Journal International Du Cancer·Emilio Ugalde-MoralesKamila Czene
Dec 24, 2018·Journal of Medical Screening·Linda PerronJacques Brisson
Aug 28, 2020·Breast Cancer Research and Treatment·Margherita PizzatoCarlo La Vecchia
Jun 30, 2019·Breast Cancer Research and Treatment·Erni LiXiaohong R Yang
Jul 31, 2019·JNCI Cancer Spectrum·Louise ErikssonKamila Czene
Mar 12, 2020·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·O Abdel-RahmanW Y Cheung
Aug 23, 2020·Scientific Reports·Silvia CascianelliEnzo Medico
Feb 23, 2020·Breast Cancer Research and Treatment·Elodia Rojas-LimaLizbeth López-Carrillo
Sep 26, 2020·International Journal of Cancer. Journal International Du Cancer·Pui San TanKamila Czene
Aug 10, 2019·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Halei C BenefieldMelissa A Troester
Sep 22, 2018·Molecular Cancer Research : MCR·He ShenJianmin Zhang
Jan 5, 2021·Breast Cancer Research and Treatment·Geffen KleinsternCeline M Vachon
Oct 25, 2020·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Halei C BenefieldMelissa A Troester
Mar 20, 2021·Breast Cancer Research : BCR·Jonine D FigueroaThomas E Rohan
Mar 24, 2021·International Journal of Epidemiology·Amber N HursonUNKNOWN B-CAST Risk Modelling Group
Jul 1, 2021·Journal of Cellular and Molecular Medicine·Ting YeJinbo Liu
Aug 4, 2021·Breast Cancer Research and Treatment·Tara M Friebel-KlingnerAnne Marie McCarthy
Sep 1, 2021·Cancer Medicine·Anne Marie McCarthyKatrina Armstrong

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