Assessment of bronchial beta blockade after oral bevantolol

Clinical Pharmacology and Therapeutics
A D MackayA E Tattersfield

Abstract

We have applied a new method for quantitative measurement of bronchial beta adrenoceptor blockade to a new beta adrenoceptor antagonist, bevantolol. Dose-response curves to a beta agonist, albuterol, were obtained in six normal subjects by measuring specific airway conductance (sGaw) after increasing doses of inhaled albuterol. These were repeated on three separate occasions 2 hr after subjects had taken oral placebo or bevantolol (75 or 150 mg), double-blind in random order. The dose-response curves after bevantolol 75 mg were displaced in the right of placebo in four subjects and after 150 mg were displaced to the right of placebo in all subjects. The mean dose ratios for bevantolol 75 or 150 mg were 1.02 and 2.77, much the same as those obtained in the same subjects after practolol 100 and 200 mg and considerably less than that after propranolol 40 mg. The mean reductions in exercise heart rate were 25% and 29% after bevantolol 75 and 150 mg. Our data show that bronchial beta blockade after a beta blocking drug can be assessed quantitatively in many by a double-blind technique.

Citations

Dec 1, 1987·Journal of Clinical Pharmacology·S NattelJ McCans
Jul 1, 1981·British Journal of Clinical Pharmacology·H R GribbinA E Tattersfield
Jan 1, 1983·European Journal of Clinical Pharmacology·R Palminteri, G Kaik
Sep 1, 1984·British Journal of Clinical Pharmacology·A E TattersfieldR J Bacon
Jul 1, 1987·Journal of Clinical Pharmacology·E M Vaughan Williams
Dec 1, 1983·British Journal of Clinical Pharmacology·A E Tattersfield, D J Cragg
Jan 1, 1986·European Journal of Clinical Pharmacology·P Vermeij, P van Brummelen

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adrenergic Receptors: Trafficking

Adrenergic receptor trafficking is an active physiological process where adrenergic receptors are relocated from one region of the cell to another or from one type of cell to another. Discover the latest research on adrenergic receptor trafficking here.

Asthma

This feed focuses in Asthma in which your airways narrow and swell. This can make breathing difficult and trigger coughing, wheezing and shortness of breath.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.