The depth of a burn wound and/or its healing potential are the most important determinants of the therapeutic management and of the residual morbidity or scarring. Traditionally, burn surgeons divide burns into superficial which heal by rapid re-epithelialization with minimal scarring and deep burns requiring surgical therapy. Clinical assessment remains the most frequent technique to measure the depth of a burn wound although this has been shown to be accurate in only 60-75% of the cases, even when carried out by an experienced burn surgeon. In this article we review all current modalities useful to provide an objective assessment of the burn wound depth, from simple clinical evaluation to biopsy and histology and to various perfusion measurement techniques such as thermography, vital dyes, video angiography, video microscopy, and laser Doppler techniques. The different needs according to the different diagnostic situations are considered. It is concluded that for the initial emergency assessment, the use of telemetry and simple burn photographs are the best option, that for research purposes a wide range of different techniques can be used but that, most importantly, for the actual treatment decisions, laser Doppler imaging i...Continue Reading
Multispectral photographic analysis. A new quantitative tool to assist in the early diagnosis of thermal burn depth
Effects of allopurinol, ibuprofen and cyclosporin A on local microcirculatory disturbance due to burn injuries
The use of laser Doppler imaging as an aid in clinical management decision making in the treatment of vesicant burns
Blood flow and oxygenation in peritendinous tissue and calf muscle during dynamic exercise in humans
Diagnosis of burn depth using laser-induced indocyanine green fluorescence: a preliminary clinical trial
In vivo burn depth determination by high-speed fiber-based polarization sensitive optical coherence tomography
Contrast mechanisms in polarization-sensitive Mueller-matrix optical coherence tomography and application in burn imaging
Laser Doppler imaging determines need for excision and grafting in advance of clinical judgment: a prospective blinded trial
The influence of dressings and ointments on the qualitative and quantitative evaluation of burn wounds by ICG video-angiography: an experimental setup
Observations on the microcirculation of the human burn wound using orthogonal polarization spectral imaging
Laser Doppler imaging of paediatric burns: burn wound outcome can be predicted independent of clinical examination
Evidence for the link between healing time and the development of hypertrophic scars (HTS) in paediatric burns due to scald injury
Assessment of burn depth: a prospective, blinded comparison of laser Doppler imaging and videomicroscopy
A technique based on laser Doppler flowmetry and photoplethysmography for simultaneously monitoring blood flow at different tissue depths
Noninvasive and high-resolution optical monitoring of healing of diabetic dermal excisional wounds implanted with biodegradable in situ gelable hydrogels
Using ordinal logistic regression to evaluate the performance of laser-Doppler predictions of burn-healing time
Objective assessment of endogenous collagen in vivo during tissue repair by laser induced fluorescence
Innovative use of povidone-iodine to guide burn wound debridement and predict the success of biobrane as a definitive treatment for burns
Comparison of efficacy of topical phenytoin with hypericin in second-degree burn wound healing: an experimental study in rats
Epidemiology and outcome analysis of severe extensive burns: a 12-year summary of 103 cases in a burn center in China
Advances in Skin Substitutes-Potential of Tissue Engineered Skin for Facilitating Anti-Fibrotic Healing
Microvascular blood flow in scalds in children and its relation to duration of wound healing: A study using laser speckle contrast imaging
A comparative study of 1% silver sulphadiazine (Flammazine®) versus an enzyme alginogel (Flaminal®) in the treatment of partial thickness burns
Investigation of the skin repair and healing mechanism of N-carboxymethyl chitosan in second-degree burn wounds
Extra-large negative pressure wound therapy dressings for burns - Initial experience with technique, fluid management, and outcomes
The impact of laser Doppler imaging on the early decision-making process for surgical intervention in adults with indeterminate burns
A prospective randomised clinical pilot study to compare the effectiveness of Biobrane® synthetic wound dressing, with or without autologous cell suspension, to the local standard treatment regimen in paediatric scald injuries
Forward-looking infrared imaging predicts ultimate burn depth in a porcine vertical injury progression model
Burn wound healing time assessed by laser Doppler imaging (LDI). Part 1: Derivation of a dedicated colour code for image interpretation
Cost-Effectiveness of Laser Doppler Imaging in Burn Care in The Netherlands: A Randomized Controlled Trial
Ultrasound assessed thickness of burn scars in association with laser Doppler imaging determined depth of burns in paediatric patients
Examination of the Early Diagnostic Applicability of Active Dynamic Thermography for Burn Wound Depth Assessment and Concept Analysis
Epidemiology and outcome analysis of hand burns: A 5-year retrospective review of 378 cases in a burn center in Eastern China
Non-invasive assessment of healing of bacteria infected and uninfected wounds using optical coherence tomography
Histopathologic staining of low temperature cutaneous burns: comparing biomarkers of epithelial and vascular injury reveals utility of HMGB1 and hematoxylin phloxine saffron
Fibrin biomatrix-conjugated platelet-derived growth factor AB accelerates wound healing in severe thermal injury
Deep dermal fibroblast profibrotic characteristics are enhanced by bone marrow-derived mesenchymal stem cells
Nonsilver treatment vs. silver sulfadiazine in treatment of partial-thickness burn wounds in children: a systematic review and meta-analysis
Deep partial thickness burn blister fluid promotes neovascularization in the early stage of burn wound healing
Utilization of laser Doppler flowmetry and tissue spectrophotometry for burn depth assessment using a miniature swine model
Differential collagen-glycosaminoglycan matrix remodeling by superficial and deep dermal fibroblasts: potential therapeutic targets for hypertrophic scar
A topical aqueous oxygen emulsion stimulates granulation tissue formation in a porcine second-degree burn wound
Acute discrimination between superficial-partial and deep-partial thickness burns in a preclinical model with laser speckle imaging
Comparison of Laser Doppler and Laser-Assisted Indocyanine Green Angiography Prediction of Flap Survival in a Novel Modification of the McFarlane Flap
Combined ultrasound and photoacoustic imaging to noninvasively assess burn injury and selectively monitor a regenerative tissue-engineered construct
Cross-sectional evaluation of the prevalence and factors associated with soft tissue scarring after the removal of miniscrews
Aquacel(®) Ag dressing versus Acticoat™ dressing in partial thickness burns: a prospective, randomized, controlled study in 100 patients. Part 1: burn wound healing
Randomized placebo-controlled trial of sucrose analgesia on neonatal skin blood flow and pain response during heel lance
Time to wound closure in trauma patients with disorders in wound healing is shortened by supplements containing antioxidant micronutrients and glutamine: a PRCT
The role of silver sulphadiazine in the conservative treatment of partial thickness burn wounds: A systematic review
Lack of a standardised UK care pathway resulting in national variations in management and outcomes of paediatric small area scalds
Demonstration of the test-retest reliability and sensitivity of the Lower Limb Functional Index-10 as a measure of functional recovery post burn injury: a cross-sectional repeated measures study design
Diagnostic accuracy of laser Doppler imaging in burn depth assessment: Systematic review and meta-analysis
High-resolution harmonics ultrasound imaging for non-invasive characterization of wound healing in a pre-clinical swine model
Long-term scar quality in burns with three distinct healing potentials: A multicenter prospective cohort study
Assessing effect of three herbal medicines in second and third degree burns in rats and comparison with silver sulfadiazine ointment
Dermal Fibroblasts from Different Layers of Pig Skin Exhibit Different Profibrotic and Morphological Characteristics
Methodological concerns with laser speckle contrast imaging in clinical evaluation of microcirculation
Accuracy of acute burns diagnosis made using smartphones and tablets: a questionnaire-based study among medical experts
Development and validation of an algorithm to predict the treatment modality of burn wounds using thermographic scans: Prospective cohort study
Patient-reported scar quality of adults after burn injuries: A five-year multicenter follow-up study
Indocyanine green dye angiography as an adjunct to assess indeterminate burn wounds: A prospective, multicentered, triple-blinded study
Diagnostic Accuracy of Laser Doppler Imaging for the Assessment of Burn Depth: A Meta-analysis and Systematic Review
Preliminary Assessment of Burn Depth by Paper-Based ELISA for the Detection of Angiogenin in Burn Blister Fluid-A Proof of Concept
Dermis, acellular dermal matrix, and fibroblasts from different layers of pig skin exhibit different profibrotic characteristics: evidence from in vivo study
mHealth for image-based diagnostics of acute burns in resource-poor settings: studies on the role of experts and the accuracy of their assessments.
Evidence-based injury prediction data for the water temperature and duration of exposure for clinically relevant deep dermal scald injuries
Improvement in burn wound care: summary of the AWMF guideline for the treatment of thermal injuries in adults
Quantitative assessments of burn degree by high-frequency ultrasonic backscattering and statistical model
Hydrosurgical debridement versus conventional surgical debridement for acute partial-thickness burns
Enzymatic debridement for burn wound care: Interrater-reliability and impact of experience in post-intervention therapy decision
Recommendations for burns care in mass casualty incidents: WHO Emergency Medical Teams Technical Working Group on Burns (WHO TWGB) 2017-2020.
Quantitative Evaluation of Burn Injuries Based on Electrical Impedance Spectroscopy of Blood with a Seven-Parameter Equivalent Circuit.
An Inconvenient Truth of Clinical Assessment and Indocyanine Green Angiography Precise Marking for Indeterminate Burn Excision.
Letter to the Editor in response to "Lower limb functional status and its determinants in moderate/major burns 3-6 months following injury: A two-center observational study".
Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.
Evolution of Pluripotency
Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.
Lipidomics & Rhinovirus Infection
Lipidomics can be used to examine the lipid species involved with pathogenic conditions, such as viral associated inflammation. Discovered the latest research on Lipidomics & Rhinovirus Infection.
Spatio-Temporal Regulation of DNA Repair
DNA repair is a complex process regulated by several different classes of enzymes, including ligases, endonucleases, and polymerases. This feed focuses on the spatial and temporal regulation that accompanies DNA damage signaling and repair enzymes and processes.
Chronic Fatigue Syndrome
Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.
Torsion dystonia is a movement disorder characterized by loss of control of voluntary movements appearing as sustained muscle contractions and/or abnormal postures. Here is the latest research.
Archaeal RNA Polymerase
Archaeal RNA polymerases are most similar to eukaryotic RNA polymerase II but require the support of only two archaeal general transcription factors, TBP (TATA-box binding protein) and TFB (archaeal homologue of the eukaryotic general transcription factor TFIIB) to initiate basal transcription. Here is the latest research on archaeal RNA polymerases.
Alzheimer's Disease: MS4A
Variants within the membrane-spanning 4-domains subfamily A (MS4A) gene cluster have recently been implicated in Alzheimer's disease in genome-wide association studies. Here is the latest research on Alzheimer's disease and MS4A.
Central Pontine Myelinolysis
Central Pontine Myelinolysis is a neurologic disorder caused most frequently by rapid correction of hyponatremia and is characterized by demyelination that affects the central portion of the base of the pons. Here is the latest research on this disease.