Abstract
Although axillary lymph nodes status, tumour size, hormonal-receptor status and histological grade at diagnosis are frequently used to orient the treatment of breast cancer patients, some tumours recur in patients with early stage disease. Pre-operative assessment of individual tumour characteristics, based on oncogenes and growth factors related to tumour growth, invasion or metastasis, may guide the treatment for patients with breast carcinomas. We examine here the prognostic significance of cyclin D1, urokinase type plasminogen activator, vascular endothelial growth factor (VEGF), platelet-derived growth factor, and c-erbB2 expression in pre-operatively obtained fine-needle aspirates from breast carcinomas less than or equal to 3 cm in size. Correlation between mRNA expression of these factors and clinicopathological characteristics was analysed. The level of c-erbB2 mRNA expression was significantly higher in tumours with lymph node metastases than in those without lymph node metastases. VEGF mRNA expression positively correlated with the degree of angiogenesis as quantitated by immunohistological staining with a CD31 monoclonal antibody. Analysis of c-erbB2 and VEGF mRNA expression in fine-needle aspirates may be useful in...Continue Reading
References
Dec 16, 1992·Journal of the National Cancer Institute·N WeidnerG Gasparini
Oct 1, 1992·American Journal of Surgery·A OsakiT Toge
Dec 1, 1991·Breast Cancer Research and Treatment·S AriadW R Bezwoda
Jan 3, 1991·The New England Journal of Medicine·N WeidnerJ Folkman
May 17, 1991·Cell·Y XiongD Beach
Sep 1, 1990·Journal of Clinical Pathology·D V ParumsD Y Mason
Dec 8, 1989·Science·P J KeckD T Connolly
Jan 16, 1986·Nature·T YamamotoK Toyoshima
Apr 24, 1986·Nature·C BetsholtzA L Mellor
Apr 1, 1981·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·S M HsuH Fanger
Feb 10, 1984·Nucleic Acids Research·P PonteL Kedes
Dec 1, 1995·Nature Medicine·D Weinstat-SaslowP S Steeg
Oct 1, 1994·Japanese Journal of Cancer Research : Gann·M ToiT Tominaga
May 29, 1995·International Journal of Cancer. Journal International Du Cancer·C DugganM J Duffy
Jun 1, 1995·Annals of Surgery·K I BlandH J Wanebo
Apr 16, 1994·Lancet·I A RobinsonM W Kissin
Dec 1, 1994·Cancer·L C HartmannP C Roche
Jan 1, 1994·Cancer·G K SchwartzA P Albino
Mar 1, 1996·Surgery·K AnanM Torisu
Citations
Jun 19, 2001·International Journal of Cancer. Journal International Du Cancer·M MitasD J Cole
Jul 14, 2005·Investigational New Drugs·Beata KosmiderPawel Liberski
Oct 14, 2003·American Journal of Surgery·Megan BakerDavid J Cole
May 29, 2004·Annals of Surgery·William E GillandersDavid J Cole
May 31, 2006·Human Pathology·Pamela PinzaniClaudio Orlando
Mar 5, 2008·Cancer Investigation·F IovinoF De Vita
Dec 9, 2000·Radiology·R MatsubayashiS Kudo
Nov 29, 2013·The Journal of Biological Chemistry·Chengshan XuZhihua Liu
Nov 7, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Edward J FilardoEdmond Sabo
Aug 24, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Neslihan CabiogluAysegul Sahin
Sep 29, 2004·Cytokine & Growth Factor Reviews·Keping XieSuyun Huang