PMID: 9542512Apr 18, 1998Paper

Assessment of c-erbB2 and vascular endothelial growth factor mRNA expression in fine-needle aspirates from early breast carcinomas: pre-operative determination of malignant potential

European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
K AnanM Tanaka

Abstract

Although axillary lymph nodes status, tumour size, hormonal-receptor status and histological grade at diagnosis are frequently used to orient the treatment of breast cancer patients, some tumours recur in patients with early stage disease. Pre-operative assessment of individual tumour characteristics, based on oncogenes and growth factors related to tumour growth, invasion or metastasis, may guide the treatment for patients with breast carcinomas. We examine here the prognostic significance of cyclin D1, urokinase type plasminogen activator, vascular endothelial growth factor (VEGF), platelet-derived growth factor, and c-erbB2 expression in pre-operatively obtained fine-needle aspirates from breast carcinomas less than or equal to 3 cm in size. Correlation between mRNA expression of these factors and clinicopathological characteristics was analysed. The level of c-erbB2 mRNA expression was significantly higher in tumours with lymph node metastases than in those without lymph node metastases. VEGF mRNA expression positively correlated with the degree of angiogenesis as quantitated by immunohistological staining with a CD31 monoclonal antibody. Analysis of c-erbB2 and VEGF mRNA expression in fine-needle aspirates may be useful in...Continue Reading

References

Dec 16, 1992·Journal of the National Cancer Institute·N WeidnerG Gasparini
Jan 3, 1991·The New England Journal of Medicine·N WeidnerJ Folkman
May 17, 1991·Cell·Y XiongD Beach
Apr 1, 1981·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·S M HsuH Fanger
May 29, 1995·International Journal of Cancer. Journal International Du Cancer·C DugganM J Duffy
Jan 1, 1994·Cancer·G K SchwartzA P Albino

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Citations

Jun 19, 2001·International Journal of Cancer. Journal International Du Cancer·M MitasD J Cole
Oct 14, 2003·American Journal of Surgery·Megan BakerDavid J Cole
Nov 7, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Edward J FilardoEdmond Sabo
Aug 24, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Neslihan CabiogluAysegul Sahin
Sep 29, 2004·Cytokine & Growth Factor Reviews·Keping XieSuyun Huang

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