Assessment of cardiac autonomic tone in conscious rats

Autonomic Neuroscience : Basic & Clinical
Halil SayinClaude Julien

Abstract

Cardiac autonomic tone can be assessed either by estimating separately vagal and sympathetic tones or by evaluating the net effect of their interaction, the so-called sympathovagal balance (SVB). To compare the most commonly used methods in rats, telemetric recordings of the electrocardiogram were performed in normotensive WKY rats, and in groups of spontaneously hypertensive (SHR) rats that were either untreated or chronically treated with the cholinesterase inhibitor, pyridostigmine, to enhance vagal tone. Cardiac autonomic blockers were administered alone and in combination, so that heart rate (HR) could be measured (1) under resting conditions, (2) with either autonomic branch blocked, and (3) with both branches blocked (which provided intrinsic HR, iHR). SVB was assessed as the ratio of resting HR to iHR. This calculation pointed to a sympathetic predominance in untreated SHRs and even more so in WKY rats, and to a marked vagal predominance in pyridostigmine-treated SHRs. By contrast, the ratio between low and high frequency components (LF/HF) of RR interval spectra did not significantly differ between the groups. Each autonomic tone was quantified as the HR change induced by its selective blocker or as the difference betw...Continue Reading

References

Jun 1, 1990·Journal of the Autonomic Nervous System·N JapundzicJ L Elghozi
Nov 1, 1971·Circulation Research·M N Levy
Dec 31, 1997·Circulation·D L Eckberg
Mar 3, 1998·The Journal of Physiology·R LétienneC Julien
Sep 28, 1998·Archives des maladies du coeur et des vaisseaux·V Safa-TisserontJ L Elghozi
Feb 22, 2000·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·H B LillywhiteA P Farrell
Mar 2, 2002·Autonomic Neuroscience : Basic & Clinical·José Dias da Silva ValdoNicola Montano
Jan 25, 2005·Autonomic Neuroscience : Basic & Clinical·Tomohiro KawaguchiMasayoshi Kuwahara
Jun 4, 2005·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Delphine BertramClaude Julien
Dec 20, 2005·Cardiovascular Research·Claude Julien
Jul 20, 2007·Fundamental & Clinical Pharmacology·Jean-Luc Elghozi, Claude Julien
Sep 5, 2009·Journal of Molecular and Cellular Cardiology·J YanniH Dobrzynski
Jun 5, 2012·American Journal of Physiology. Heart and Circulatory Physiology·Alina ScridonPhilippe Chevalier
Feb 23, 2013·Frontiers in Physiology·George E Billman
May 25, 2013·Clinical and Experimental Pharmacology & Physiology·Raquel N de La FuenteMaria-Cláudia Irigoyen
Aug 21, 2013·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Renata M LataroHelio C Salgado
Jun 8, 2014·Physiology & Behavior·Jessica Saalfield, Linda Spear
Nov 25, 2014·American Journal of Physiology. Heart and Circulatory Physiology·Fernanda Machado Santos-AlmeidaRubens Fazan
May 16, 2015·European Heart Journal·John S Floras, Piotr Ponikowski
Jun 6, 2015·Circulation Research·Marc W DeyellJeffrey J Goldberger
Jul 16, 2015·Clinical and Experimental Pharmacology & Physiology·Halil SayinClaude Julien
Sep 6, 2015·American Journal of Physiology. Heart and Circulatory Physiology·Morgayn I ReadIvan A Sammut

❮ Previous
Next ❯

Citations

Sep 7, 2016·Autonomic Neuroscience : Basic & Clinical·Heidi L LujanStephen E DiCarlo
Aug 18, 2017·Scientific Reports·Luiz Eduardo Virgilio SilvaRubens Fazan

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.