Assessment of cardiovascular regulation after burns by nonlinear analysis of the electrocardiogram

Journal of Burn Care & Research : Official Publication of the American Burn Association
Andriy I BatchinskyLeopoldo C Cancio

Abstract

Critical illness and hypovolemia are associated with loss of complexity of the R-to-R interval (RRI) of the electrocardiogram, whereas recovery is characterized by restoration thereof. Our goal was to investigate the dynamics of RRI complexity in burn patients. We hypothesized that the postburn period is associated with a state of low RRI complexity, and that successful resuscitation restores it. Electrocardiogram was acquired from 13 patients (age 55 +/- 5 years, total body surface area burned 36 +/- 6%, 11 +/- 5% full thickness) at 8, 12, 24, and 36 hours during postburn resuscitation. RRI complexity was quantified by approximate entropy (ApEn) and sample entropy (SampEn) that measure RRI signal irregularity, as well as by symbol distribution entropy and bit-per-word entropy that assess symbol sequences within the RRI signal. Data (in arbitrary units) are means +/- SEM. All patients survived resuscitation. Changes in heart rate and blood pressure were not significant. ApEn at 8 hours was abnormally low at 0.89 +/- 0.06. ApEn progressively increased after burn to 1.22 +/- 0.04 at 36 hours. SampEn showed similar significant changes. Symbol distribution entropy and bit-per-word entropy increased with resuscitation from 3.63 +/- ...Continue Reading

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Citations

Mar 17, 2009·Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine·David J Dries
Feb 26, 2011·Anesthesiology Research and Practice·Mark L RyanKenneth G Proctor
Jun 11, 2015·Journal of Burn Care & Research : Official Publication of the American Burn Association·Michael J LoguidiceEllen C Keeley
Oct 14, 2008·The Journal of Trauma·Leopoldo C CancioJohn B Holcomb
Feb 23, 2010·The Journal of Trauma·Andriy I BatchinskyLeopoldo C Cancio
Sep 26, 2013·The Journal of Trauma and Acute Care Surgery·Ali Y MejaddamDavid Richard King
Aug 27, 2009·Critical Care Medicine·Barbara A Latenser
Oct 27, 2009·Burns : Journal of the International Society for Burn Injuries·Steven E Wolf

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