Assessment of cellular immune parameters in paediatric toxic shock syndrome: a report of five cases

FEMS Immunology and Medical Microbiology
O DauwalderGuillaume Monneret

Abstract

Toxic shock syndrome (TSS) and septic shock (SS) share many clinical signs of an exacerbated inflammatory response. In this report, we investigated whether TSS presents similar features of delayed immunosuppression as described in SS. Five children with TSS from paediatric intensive care units in a university hospital were monitored. TSS cases were defined by the association of standardized clinical signs of TSS and confirmed by measurement of specific Vbeta expansions corresponding to toxin gene profile of the isolated strains. As in SS, an increased percentage of circulating regulatory T cells (Treg) was observed in patients with TSS. However, in contrast to SS, neither lymphopenia nor decreased HLA-DR expression on monocytes was measured. In conclusion, whereas SS and TSS exhibited similar clinical presentation, the present observation suggests that respective pathophysiological mechanisms induce different immune alterations. Future studies must isolate and better characterize the phenotypic and functional properties of Treg subsets during TSS to understand the mechanisms sustaining their increase, especially the putative role of superantigens.

References

Dec 22, 1999·Emerging Infectious Diseases·R A HajjehB A Perkins
Jun 3, 2006·Intensive Care Medicine·Guillaume MonneretPhilippe Vanhems
Mar 21, 2007·Chemical Immunology and Allergy·Damien ThomasGerard Lina
Oct 4, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Aharon KesselElias Toubi
Oct 13, 2007·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·E DesclouxJ Etienne
Nov 21, 2007·Molecular Medicine·Guillaume MonneretAlain Lepape
Apr 1, 2008·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·T FerryJ Etienne
Mar 4, 2009·Infection and Immunity·Damien ThomasGerard Lina
Apr 28, 2009·The Lancet Infectious Diseases·Emma Lappin, Andrew J Ferguson
Jan 12, 2010·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·S HenrietA Faye
Jun 19, 2010·Nature Reviews. Immunology·Shimon SakaguchiDavid A Hafler
Nov 5, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Amanda L Taylor, Martin J Llewelyn
Dec 8, 2010·Journal of Pain & Palliative Care Pharmacotherapy·UNKNOWN Centers for Disease Control and Prevention Public Health Service U. S. Department of Health and Human Services
Dec 15, 2010·Intensive Care Medicine·Mark W HallJoseph A Carcillo
Mar 8, 2011·European Journal of Immunology·Alvin W L SchadenbergBerent J Prakken
Aug 4, 2011·Cytometry. Part B, Clinical Cytometry·Christian GilleThorsten W Orlikowsky

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Citations

Oct 7, 2018·Microbiology Spectrum·Yves GilletFrancois Vandenesch

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