Assessment of cerebral autoregulation using carotid artery compression

Stroke; a Journal of Cerebral Circulation
P SmielewskiJ D Pickard

Abstract

A simple method of testing cerebral autoregulation by observing transcranial Doppler changes in middle cerebral artery flow velocity (FV) during a brief ipsilateral carotid artery compression (the transient hyperemic response test) was studied in 11 normal healthy volunteers. The aim of this study was to assess the reliability of the method and to compare derived autoregulatory indices with those of a standard noninvasive test of autoregulation, Aaslid's leg-cuff test. Volunteers were subjected to repeated carotid compressions and leg-cuff tests at different levels of CO2. Hypercapnia was induced using inhalation of a mixture of 5% CO2 in air. Hypocapnia was induced by moderate hyperventilation. To assess the influence of the duration of carotid compression, a series of carotid compressions lasting 3, 4, 5, 7, and 9 seconds were performed in random sequence. Monitored parameters included ipsilateral FV, end-tidal CO2, and arterial blood pressure. The transient hyperemic response ratio (THRR), calculated as the maximum increase of FV divided by baseline values after release of the carotid compression, was taken as the autoregulation index. This index was compared with the rate of autoregulation index derived from the leg-cuff te...Continue Reading

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Citations

Aug 1, 1997·International Journal of Clinical Monitoring and Computing·P SmielewskiJ D Pickard
Jul 19, 2001·Annals of the New York Academy of Sciences·R SchondorfR Stein
Dec 13, 2012·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Karol P BudohoskiPeter J Kirkpatrick
Feb 18, 2016·Journal of Neurosurgical Anesthesiology·Jeffrey J Pasternak, William L Lanier
Jun 22, 2018·Medicine and Science in Sports and Exercise·M Erin MoirJ Kevin Shoemaker
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May 1, 1997·Journal of Neurosurgery·P SmielewskiJ D Pickard
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