Assessment of cerebral glucose metabolism in patients with heart failure by 18 F-FDG PET/CT imaging

Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology
Mingkai YunXiaoli Zhang

Abstract

To evaluate the cerebral metabolism in patients with heart failure (HF). One hundred and two HF patients were prospectively enrolled, who underwent gated 99mTc-sestamibi single photon emission computed tomography (SPECT)/CT, cardiac and cerebral 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET)/CT. Fifteen healthy volunteers served as controls. Patients were stratified by extent of hibernating myocardium (HM) and left ventricular ejection fraction (LVEF) into 4 groups where Group1: HM < 10% (n = 33); Group2: HM ≥ 10%, LVEF < 25% (n = 34); Group3: HM ≥ 10%, 25% ≤ LVEF ≤ 40% (n = 16) and Group 4: LVEF > 40% (n = 19). The standardized uptake value (SUV) in the whole brain (SUVwhole-brain) and the SUV ratios (SUVR) in 24 cognition-related brain regions were determined. SUVwhole-brain and SUVRs were compared between the 4 patient groups and the healthy controls. SUVwhole-brain (r = 0.245, P = 0.013) and SUVRs in frontal areas, hippocampus, and para-hippocampus (r: 0.213 to 0.308, all P < 0.05) were correlated with HM. SUVwhole-brain differed between four patient groups and the healthy volunteers (P = 0.016) and SUVwhole-brain in Group 1 was lower than that in healthy volunteers (P < 0.05). SUVRs of Group 3 in frontal a...Continue Reading

References

Feb 28, 2002·Psychiatry Research·Mark W WillisRobert M Post
Apr 12, 2002·The American Journal of Pathology·Nikolaos G FrangogiannisWilliam A Zoghbi
Aug 2, 2003·The American Journal of Medicine·Giuseppe ZuccalàRoberto Bernabei
Jul 18, 2008·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Xiaoli ZhangHeinrich R Schelbert
Oct 20, 2009·European Journal of Nuclear Medicine and Molecular Imaging·Andrea VarroneUNKNOWN European Association of Nuclear Medicine Neuroimaging Committee
Jan 5, 2013·European Journal of Nuclear Medicine and Molecular Imaging·Xiaoli ZhangHeinrich R Schelbert
May 14, 2014·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Richard K J BrownKirk A Frey
Apr 22, 2015·Circulation Journal : Official Journal of the Japanese Circulation Society·Min-Seok Kim, Jae-Joong Kim
Jul 10, 2016·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Vasken DilsizianMark I Travin
Mar 25, 2017·Journal of the American College of Cardiology·Ofer HavakukRobert A Kloner
Jun 1, 2017·European Journal of Heart Failure·Bhaswati RoyRajesh Kumar
Mar 16, 2018·European Journal of Heart Failure·Pavla Cermakova
Jun 11, 2018·JACC. Heart Failure·Susan J Pressler, Miyeon Jung
Mar 10, 2019·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·James T Thackeray
May 15, 2019·European Heart Journal Cardiovascular Imaging·Michael FiechterCatherine Gebhard
Oct 1, 2019·Journal of the American Heart Association·Michael FiechterCatherine Gebhard
Dec 7, 2019·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Pablo BascuñanaJames T Thackeray

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Citations

Nov 27, 2020·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Qian Wang
Aug 31, 2021·Oxidative Medicine and Cellular Longevity·Chengyang XuZhipeng Cao

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