Assessment of cerebral hemodynamics in childhood moyamoya disease using a quantitative and a semiquantitative IMP-SPECT study

Annals of Nuclear Medicine
Norihiro SaitoAkira Teramoto

Abstract

We evaluated the cerebral hemodynamics in childhood moyamoya disease patients before and after surgery to assess both surgical indication and the effect of revascularization using single photon emission computed tomography (SPECT) study with N-isopropyl-p-123I-iodoamphetamine (IMP). We compared results of quantitative and semi-quantitative SPECT studies to determine parameters by the semi-quantitative method to define severe hemodynamic ischemia. There were 14 pediatric patients with moyamoya disease who suffered transient ischemic attacks (TIAs) in the anterior circulation. Before and after surgical revascularization by STA-MCA bypass and encephalomyosynangiosis (EMS), quantitative IMP-SPECT studies using the autoradiographic method (IMP-ARG method) were performed. Resting regional cerebral blood flow (rCBF) and regional vascular reserve (rVR) were measured in bilateral cortical territories (ROI) and cerebellum. Semi-quantitative parameters were calculated from the ratio of ROI counts to the dominant cerebellar counts (ROI/Ce ratio) at resting and acetazolamide-activated conditions. Before surgery, the mean resting rCBF and rVR in bilateral ACA and MCA territories were less than 40 ml/100 g/min and less than 10%, respectively,...Continue Reading

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Citations

Apr 2, 2009·Neurosurgical Focus·Marco LeeGary K Steinberg
Dec 15, 2015·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Jai-Hyuck HanSang-Hoon Cha
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Jan 9, 2020·European Journal of Nuclear Medicine and Molecular Imaging·Hyun Gee RyooDong Soo Lee
Mar 25, 2020·Nuclear Medicine and Molecular Imaging·Teck Huat WongDong Soo Lee
Nov 7, 2020·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Zhao LimingLi Chaoyue

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