Assessment of cerebrospinal fluid immunoglobulin patterns after isoelectric focusing. Use of kappa and lambda light chain immunoperoxidase staining

Journal of the Neurological Sciences
R W WalkerE J Thompson

Abstract

Assessment of the presence of immunoglobulin (Ig) of restricted heterogeneity i.e. oligoclonal Ig in cerebrospinal fluid subjected to isoelectric focusing (IEF) may be difficult because of the tendency of the technique to subdivide even normal polyclonal IgG into bands and zones. Focused Ig stained by the immunoperoxidase technique for kappa and lambda light chains shows correspondence between the two patterns in the case of normal polyclonal Ig, but a marked discrepancy between kappa and lambda patterns in disorders associated with oligoclonal Ig, and kappa and lambda immunofixation makes assessment of agarose IEF separations of IgG more reliable.

References

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Citations

Jun 1, 1987·Journal of Neurology·F BraccoB Tavolato
Nov 30, 1984·Clinica Chimica Acta; International Journal of Clinical Chemistry·E J Thompson, G Keir
Sep 15, 1984·Clinica Chimica Acta; International Journal of Clinical Chemistry·S HirohataT Miyamoto
Oct 1, 1984·Journal of Clinical Pathology·U H PaluchE J Thompson
Aug 1, 1989·Journal of Neurology, Neurosurgery, and Psychiatry·M K Sharief, E J Thompson
Jan 1, 1986·Journal of Child Psychology and Psychiatry, and Allied Disciplines·K P NunnM Cohen
Jul 1, 1986·Journal of Neurology, Neurosurgery, and Psychiatry·F Bollengier
Sep 11, 2008·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Christine E ParentKenneth Petren
Jan 22, 2009·Evolution; International Journal of Organic Evolution·Edgar BenavidesJack W Sites
Sep 25, 2004·Clinical Chemistry·Edward J Thompson

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