Assessment of cerebrovascular reactivity by dynamic susceptibility contrast-enhanced MR imaging

Journal of the Neurological Sciences
N NighoghossianP Trouillas

Abstract

In patients with cerebrovascular disease the acetazolamide (ACZ) test is performed to evaluate the decrease in cerebral perfusion pressure (CPP) through the investigation of the vasomotor reactivity (VMR). This latter is currently assessed with ACZ with several methods. Recently, magnetic resonance imaging (MRI) techniques have been developed that are sensitive to stimulus-induced changes in blood flow. Dynamic susceptibility contrast material-enhanced gradient-echo MRI techniques (DSC-MRI) might be an attractive tool to assess VMR. We aimed to test the ability of DSC-MRI in the assessment of VMR. Relative hemodynamic parameters rCBV, MTT, and rCBF were evaluated at baseline after the first injection of gadopentetate dimeglumine and 10 min after the intravenous administration of ACZ (1 g) with a second bolus of contrast agent. Assessment of hemodynamic parameters was performed over the whole hemisphere and also within regions of interest. The significances of the mean differences, before and after ACZ, were assessed with repeated-measures ANOVA with two within factors: laterality (right-left) and ACZ. DSC-MRI with ACZ test was performed in ten healthy controls (aged 51.4+/-16.2 years). The cerebral hemispheric ratio for the thr...Continue Reading

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Citations

Apr 30, 2002·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Yi-Fen YenAtsushi M Takahashi
Sep 5, 2002·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·I K AndersenL K Hansen
Oct 3, 2006·Neuroradiology·M Vittoria SpampinatoZoran Rumboldt
Dec 23, 2006·Neurologia Medico-chirurgica·Kazuya UemuraAtsuro Tsukada
Aug 26, 1998·Stroke; a Journal of Cerebral Circulation·M KluytmansM A Viergever
Jul 2, 1999·Stroke; a Journal of Cerebral Circulation·M KluytmansM A Viergever
Oct 29, 2005·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Hanzhang LuJoseph A Helpern
Jul 9, 2020·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Michael A ThomasKim-Lien Nguyen

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