Assessment of choroidal blood flow using laser speckle flowgraphy

The British Journal of Ophthalmology
Giacomo CalzettiLeopold Schmetterer

Abstract

There is considerable interest in novel techniques to quantify choroidal blood flow (CBF) in humans. In the present study, we investigated a novel technique to measure CBF based on laser speckle flowgraphy (LSFG) in healthy subjects. This study included 31 eyes of 31 healthy, non-smoking subjects aged between 19 and 74 years. A commercial LSFG instrument was used to measure choroidal vessel diameter (CVD) and relative flow volume (RFV) in choroidal vessels that were identified on fundus photos, an approach that was used previously only for retinal vessels. The reproducibility and the effect of isometric exercise on these parameters were investigated. The latter was compared with measurement of subfoveal CBF using laser Doppler flowmetry (LDF). Intraclass correlation coefficients for CVD and RFV were higher than 0.8 indicating excellent reproducibility. During isometric exercise, we observed an increase in ocular perfusion pressure of approximately 60% (P<0.001). The increase in RFV and CBF was lower, but also highly significant versus baseline (at minute 6 of isometric exercise: RFV 10.5%±4.2%, CBF 8.3%±3.6%; P<0.001 each) indicating choroidal autoregulation. LSFG may be a novel approach to study blood flow in choroidal vessels...Continue Reading

References

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Oct 19, 2016·Investigative Ophthalmology & Visual Science·Nikolaus LuftLeopold Schmetterer
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Aug 2, 2017·Progress in Retinal and Eye Research·Amir H KashaniRuikang K Wang

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Citations

Jan 15, 2019·Investigative Ophthalmology & Visual Science·Alina Popa-CherecheanuLeopold Schmetterer
Aug 22, 2020·Translational Vision Science & Technology·Giacomo CalzettiLeopold Schmetterer
May 19, 2021·Translational Vision Science & Technology·Jehwi JeonPilhan Kim
Jul 20, 2021·Progress in Retinal and Eye Research·J BrinksC J F Boon
Jul 30, 2021·Scientific Reports·Harumasa YokotaMasahiko Shimura

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BETA
pregnancy test

Software Mentioned

CSS Statistica
LSFG Analyzer

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