Assessment of citrullinated myelin by 1H-MR spectroscopy in early-onset multiple sclerosis.

AJNR. American Journal of Neuroradiology
K K OguzB Anlar

Abstract

Myelin instability and citrullinated myelin basic protein have been demonstrated in the brains of patients with chronic and fulminating forms of multiple sclerosis (MS). Our aim was to trace citrulline in the brains of patients with early-onset MS by using proton MR spectroscopy ((1)H-MR spectroscopy). A short-echo single-voxel (1)H-MR spectroscopy by using the point-resolved proton spectroscopy sequence was performed in 27 patients with MS and 23 healthy subjects. Voxels of interest were chronic demyelinating lesions (CDLs, n = 25) and normal-appearing white matter (NAWM, n = 25) on T2-weighted imaging, and when available in patients with MS, enhancing demyelinating lesions (EDLs, n = 8). Frontal white matter (WM) was studied in control subjects. N-acetylaspartate, choline, and myo-inositol (mIns)-creatine (Cr) ratios and the presence of a citrulline peak were noted. Citrulline peaks were more frequently observed in patients with MS than in control subjects (P = .035), located in the NAWM in 8/25 (32%), in CDLs in 7/25 (28%), and in EDLs of 1/8 (12.5%) patients with MS. The presence of citrulline and measured metabolite/Cr ratios was not related to age at imaging, age at disease onset, duration of disease, or number of relapse...Continue Reading

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Citations

Aug 10, 2013·Neuroimaging Clinics of North America·Alex Rovira, Juli Alonso
Apr 24, 2013·Neuroimaging Clinics of North America·Leonard H Verhey, John G Sled
Mar 17, 2010·Medical Hypotheses·Helmut Leitner
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Feb 28, 2015·BioMed Research International·Mahmut AlpayciYasemin Bayram
Apr 11, 2017·Neuroimaging Clinics of North America·Silvia N Tenembaum
Oct 19, 2017·Journal of Medicinal Chemistry·Elizabeth J Curiel TejedaLakshmi P Kotra

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