Assessment of coagulation with 6% hydroxyethyl starch 130/0.4 in cesarean section.

Korean journal of anesthesiology
Chung-Sik OhNam-Sik Woo

Abstract

Third-generation hydroxyethyl starch (HES) solutions have been developed to minimize negative effects on hemostasis. In normal pregnancy, the coagulation activity increases, reaching a maximum around term. This study examined the effects of hemodilution with HES 130/0.4 (6%) on blood coagulation in parturients in vivo and in vitro. Forty parturients scheduled for cesarean sections were assigned randomly to receive either 500 or 1,000 ml of HES 130/0.4 (6%). Rotation thromboelastometry (ROTEM®) measurements were performed before and after administering HES 130/0.4 (6%). In addition, blood samples obtained from 20 randomly selected parturients were diluted 10% to 40% using HES 130/0.4 (6%), and ROTEM® measurements were performed before and after dilution. The changes from baseline and the effects of dilution were analyzed by ROTEM® parameters. Infusions of 500 or 1,000 ml of HES 130/0.4 (6%) in the parturients altered the clot formation time, α angle, and maximal clot firmness, although all remained within normal ranges. HES 130/0.4 (6%) affected in vitro blood coagulation in parturients' blood containing 10, 20, 30, and 40% HES. The clotting time was prolonged at each dilution percentage, but remained within the normal range. Ot...Continue Reading

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Citations

May 2, 2020·Journal of Thrombosis and Haemostasis : JTH·Ariunzaya AmgalanHoma K Ahmadzia

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Methods Mentioned

BETA
cesarean section

Software Mentioned

SPSS
ROTEM®
Statistical Package for Social Science ( SPSS
InTEM®

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