Assessment of comorbidities and prognosis in patients with COPD diagnosed with the fixed ratio and the lower limit of normal: a systematic review and meta-analysis.

Respiratory Research
Huaiyu XiongJian Liu

Abstract

Currently, the diagnosis of chronic obstructive pulmonary disease (COPD) is not uniform, COPD guidelines recommend fixed ratio (FR), whereas ATS and ERS define airflow obstruction based on lower limit of normal (LLN). We aim to determine if there is difference between the two diagnostic criteria for morbidity, mortality, exacerbation. Four databases and all relevant studies from the references were searched from inception to June 25, 2019, to find studies that described the rate of comorbidity, the exacerbation rates, mortality in COPD patients. Data analysis was performed using STATA/SE 14.0 and followed the standard of Cochrane Collaboration. A sensitivity analysis was performed to find the source of heterogeneity. Thirteen studies and 154,447 participants were finally included in this meta-analysis. The 11 cohort studies and 2 cross-sectional studies were all high-quality. Patients with airflow limitation according to either FR or LLN had higher mortality (HRFR+/LLN- = 1.27, 95% CI = 1.14-1.42; HRFR-/LLN+ = 1.83, 95% CI = 1.17-2.86) than those who met neither criteria. When compared with the FR-/LLN- criteria, those who met the FR criteria were more likely to exacerbate (HR FR+/LLN- = 1.64, 95% CI = 1.09-2.46; HR FR-/LLN+ = ...Continue Reading

References

Oct 6, 1997·BMJ : British Medical Journal·M EggerC Minder
Jun 29, 2004·The European Respiratory Journal·B R CelliUNKNOWN ATS/ERS Task Force
Nov 3, 2005·The European Respiratory Journal·R PellegrinoJ Wanger
Mar 2, 2006·The European Respiratory Journal·M Orozco-LeviJ Gea
Apr 14, 2006·The European Respiratory Journal·R J HalbertD M Mannino
Sep 20, 2007·Proceedings of the American Thoracic Society·Alvar Agustí
Jun 27, 2008·The European Respiratory Journal·D M ManninoF Holguin
Apr 4, 2009·American Journal of Respiratory and Critical Care Medicine·Robab KohansalJoan B Soriano
Apr 15, 2009·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Wan C TanUNKNOWN Vancouver Burden of Obstructive Lung Disease (BOLD) Research Group
May 2, 2009·The European Respiratory Journal·P J Barnes, B R Celli
Oct 14, 2011·The New England Journal of Medicine·Jørgen VestboUNKNOWN ECLIPSE Investigators
Feb 2, 2013·International Journal of Cardiology·Susanne BrennerStefan Störk
Mar 26, 2013·Thorax·Surya P BhattUNKNOWN COPDGene Investigators
Apr 9, 2013·The European Respiratory Journal·Reinier P AkkermansTjard Schermer
Jun 1, 2013·The European Respiratory Journal·Christer JansonPeter Burney
Jun 21, 2013·PloS One·Firdaus A A Mohamed HoeseinPieter Zanen
Jul 13, 2013·Respiratory Medicine·Per Wollmer, Gunnar Engström
Feb 22, 2014·Chest·Jun SheChunxue Bai
Mar 6, 2015·Thorax·Nicolas MercadoPeter J Barnes
Apr 18, 2015·The European Respiratory Journal·Eralda TurkeshiJean-Marie Degryse
Jul 15, 2015·The New England Journal of Medicine·Peter LangeJørgen Vestbo
Dec 10, 2015·The European Respiratory Journal·Suneela ZaighamGunnar Engström
Dec 22, 2015·The International Journal of Tuberculosis and Lung Disease : the Official Journal of the International Union Against Tuberculosis and Lung Disease·K El RhaziV Garcia-Larsen
Jun 9, 2016·Tüberküloz ve toraks·Hakan GünenZeina Aoun Bacha
Jan 28, 2017·American Journal of Respiratory and Critical Care Medicine·Claus F VogelmeierAlvar Agustí
Sep 8, 2017·Respiration; International Review of Thoracic Diseases·Claudio PedoneRaffaele Antonelli Incalzi
Feb 23, 2018·PloS One·Miguel J DivoUNKNOWN EpiChron—BODE Collaborative Group
Dec 14, 2018·Respiratory Research·Alexandra LenoirLaurent P Nicod
Feb 4, 2019·Chest·Lea SatorUNKNOWN BOLD Collaborative Research Group

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May 17, 2021·Respiratory Research·Daisuke MorichikaNobuaki Miyahara

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